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- W90834935 abstract "This chapter describes the effect of gastric mucosal barrier breakers on canine alkaline secretion and transmucosal potential difference. The studies described in the chapter was designed to examine the effect of conventional mucosal barrier breakers such as ethanol, aspirin (ASA), and taurocholate sodium (TCh) applied on canine fundic mucosa on alkaline secretion (AS) and transmueosai potential difference (PD) as an indicator of mucosal integrity. The studies were performed in 24 mongrel dogs weighing 7–15 kg. Animals were fasted for 24 h before experimentation. Each dog was anesthetized with intravenous chloralose and ethyl carbamate injection. The trachea was incubated and the animal maintained on a respirator (Medipan, Respirator CLR-1, Poland) throughout the experiment. A femoral artery was cannulated and connected to a pressure transducer (Stethem) for continuous monitoring the systemic blood pressure. Ethanol at concentrations above 5% produced a stepwise increase in AS, achieving maximal value at 40%. This was accompanied by a gradual reduction in PD. It was also observed that immediately after adding 10% ethanol to the chamber, the mucosa appeared slightly hyperemic and engorged." @default.
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- W90834935 date "1981-01-01" @default.
- W90834935 modified "2023-10-12" @default.
- W90834935 title "EFFECT OF GASTRIC MUCOSAL BARRIER BREAKERS ON CANINE ALKALINE SECRETION AND TRANSMUCOSAL POTENTIAL DIFFERENCE" @default.
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- W90834935 doi "https://doi.org/10.1016/b978-0-08-026825-5.50034-6" @default.
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