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- W908365025 abstract "This chapter illustrates current information on transductional sequences involved in stimulated eicosanoid production in mononuclear phagocytes. Mononuclear phagocytes have been demonstrated to contain more esterified arachidonate in comparison with other leukocytes, with a large amount available for stimulated eicosanoid production. Multiple transductional sequences initiated by the stimuli of mononuclear phagocytes are involved in the production of eicosanoids. These are likely to include direct receptor-coupled activation of enzymes involved in the de-esterification of the arachidonate contained in cellular phospholipids. Alterations of the intracellular concentrations of several “second messengers” in response to external stimuli regulate both total eicosanoid production and the relative production of the individual classes of eicosanoids (i.e., cyclo-oxygenase products vs the leukotrienes). These regulators of eicosanoid production include intracellular calcium, intracellular pH, and the activation of protein kinase C. Investigations of the molecular mechanisms involved in stimulus-induced eicosanoid production are complicated by the apparent requirement for protein synthesis for the actions of several macrophage stimuli." @default.
- W908365025 created "2016-06-24" @default.
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- W908365025 date "1990-01-01" @default.
- W908365025 modified "2023-10-18" @default.
- W908365025 title "Chapter 14 Mechanisms Regulating the Production of Arachidonate Metabolites in Mononuclear Phagocytes" @default.
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- W908365025 doi "https://doi.org/10.1016/s0070-2161(08)60086-6" @default.
- W908365025 hasPublicationYear "1990" @default.
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