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• W908401711 abstract "Glomerular filtration rate (GFR) is considered as the best marker of kidney function. Evaluation of various prediction equations to estimate GFR is rare in our population. The aim of this study was to compare GFR estimated by various prediction equations with GFR by creatinine clearance (GFR(subscript cr)) in Bangladeshi population. Serum creatinine and 24 hours urinary creatinine concentrations were measured in 216 adult Bangladeshi subjects (100 males and 116 females). Creatinine clearance rate was calculated and adjusted for body surface area to obtain GFR(subscript cr). GFR was also calculated by CKD-EPI, MDRD4, Cockcroft-Gault, Jelliffe, Mawer, Bjornsson, Gates, Apollo-Chennai and Mayo Clinic prediction equations and compared with GFR(subscript cr). Results were expressed as mean ± SD and compared by two-tailed paired t-test, precision (r^2) and receiver-operating characteristic curve. Mean ± SD of age of the total subjects was 57.15 ± 10.96 years. The mean GFR(subscript cr) was 42.41 ± 22.95 mL/min/1.73m^2. Estimated GFR (eGFR) by CKD-EPI, MDRD4, Cockcroft-Gault, Jelliffe 1, Jelliffe 2, Mawer, Bjornsson, Gates, Apollo-Chennai and Mayo Clinic prediction equations were 8.19 ± 13.80, 5.30 ± 13.61, 11.54 ± 16.86, 8.66 ± 18.64, 17.25 ± 19.98, 10.86 ± 22.48, 14.60 ± 17.92, 12.18 ± 16.42, 39.86 ± 21.96 and 20.47 ± 20.49 mL/min/1.73m^2 higher than GFR(subscript cr) (P ＜ 0.001). The precision (r^2) of eGFRs were 0.7114, 0.6924, 0.6431, 0.4802, 0.5048, 0.5921, 0.6286, 0.6158, 0.1635 and 0.5586 for CKD-EPI, MDRD4, Cockcroft-Gault, Jelliffe 1, Jelliffe 2, Mawer, Bjornsson, Gates, Apollo-Chennai and Mayo Clinic prediction equations, respectively. The area under receiver-operating characteristic curve was the lowest for MDRD4 equation. This study revealed that GFR estimated by standardized MDRD4 variables equation is closer to creatinine clearance rate in the study population." @default.
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• W908401711 date "2012-03-01" @default.
• W908401711 modified "2023-09-23" @default.
• W908401711 title "Comparison of GFR by Creatinine Clearance with Estimated GFR by Various Prediction Equations in a Bangladeshi Population" @default.
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