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- W90862011 abstract "Decreasing body temperature to 32°C by liquid ventilation with perfluorocarbons is highly potent at protecting against myocardial infarction in animal models. It is well tolerated hemodynamically and offers possible translation in the resuscitation setting. Perfluorocarbons can indeed use the lung as heat exchangers while maintaining gas exchanges. Although severe hypothermia (<20°C) is known to preserve cardiac ATP content, such a mechanism can not entirely explain the benefit of mild hypothermia (32°C) with liquid ventilation. Accordingly, we investigated whether this could also involve the protection of mitochondria by preserving the mitochondrial respiratory chain. For this purpose, anesthetized rabbits were submitted to 30-min of coronary artery occlusion (CAO) under normothermic conditions (Control group) or with mild hypothermia at 32°C induced by liquid ventilation (MH group). At the end of CAO, mitochondria were isolated from ischemic myocardial areas. In MH, the respiratory control ratio was inc..." @default.
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- W90862011 date "2010-11-23" @default.
- W90862011 modified "2023-09-28" @default.
- W90862011 title "Abstract 13042: Mild Hypothermia Through Liquid Ventilation Improves Mitochondrial Respiratory Chain Activity and Maintains Reverse Electron Transport Following Myocardial Ischemia." @default.
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