Matches in SemOpenAlex for { <https://semopenalex.org/work/W9104927> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W9104927 endingPage "84.10" @default.
- W9104927 startingPage "84.10" @default.
- W9104927 abstract "Abstract Older individuals respond poorly to vaccination. B lymphocytes are responsible for the synthesis of antibodies that are generated in response to infection and vaccination. Our laboratory has shown that activated human B cells isolated from younger subjects (18-35 years old) express cyclooxygenase-2 (Cox-2) and that inhibition of Cox-2 by non-steroidal anti-inflammatory drugs (NSAIDs) blunts antibody production. However, NSAIDs are highly used by people over 60 years old. There is no information regarding Cox-2 expression in B cells in older human subjects (over 60 years old). We hypothesize that Cox-2 activity is reduced in B cells from older individuals. Young (18-35 years old) and older subjects (over 60 years old) were enrolled in the study. B cells were isolated from peripheral blood, stimulated in vitro with anti-Ig plus ODN CpG 2395 in the presence or absence of NSAIDs and Cox-2 expression, prostaglandin production, cytokines and antibody synthesis determined. Cell viability and proliferation were also assayed. Compared to younger subjects, B cells from older volunteers had reduced Cox-2 expression and also produced less antibody. Furthermore, in these individuals, antibody levels were further decreased by NSAIDs. Thus, NSAIDs and low intrinsic Cox-2 expression could be responsible for the poor antibody response to vaccination in the elderly." @default.
- W9104927 created "2016-06-24" @default.
- W9104927 creator A5064982745 @default.
- W9104927 creator A5071941143 @default.
- W9104927 date "2010-04-01" @default.
- W9104927 modified "2023-09-25" @default.
- W9104927 title "Non-steroidal anti-inflammatory drugs blunt antibody production in human B lymphocytes from older volunteer (84.10)" @default.
- W9104927 doi "https://doi.org/10.4049/jimmunol.184.supp.84.10" @default.
- W9104927 hasPublicationYear "2010" @default.
- W9104927 type Work @default.
- W9104927 sameAs 9104927 @default.
- W9104927 citedByCount "0" @default.
- W9104927 crossrefType "journal-article" @default.
- W9104927 hasAuthorship W9104927A5064982745 @default.
- W9104927 hasAuthorship W9104927A5071941143 @default.
- W9104927 hasConcept C126322002 @default.
- W9104927 hasConcept C159654299 @default.
- W9104927 hasConcept C16685009 @default.
- W9104927 hasConcept C181199279 @default.
- W9104927 hasConcept C202751555 @default.
- W9104927 hasConcept C203014093 @default.
- W9104927 hasConcept C22070199 @default.
- W9104927 hasConcept C2777956040 @default.
- W9104927 hasConcept C2779689624 @default.
- W9104927 hasConcept C2780664492 @default.
- W9104927 hasConcept C55493867 @default.
- W9104927 hasConcept C71924100 @default.
- W9104927 hasConcept C86803240 @default.
- W9104927 hasConcept C98274493 @default.
- W9104927 hasConceptScore W9104927C126322002 @default.
- W9104927 hasConceptScore W9104927C159654299 @default.
- W9104927 hasConceptScore W9104927C16685009 @default.
- W9104927 hasConceptScore W9104927C181199279 @default.
- W9104927 hasConceptScore W9104927C202751555 @default.
- W9104927 hasConceptScore W9104927C203014093 @default.
- W9104927 hasConceptScore W9104927C22070199 @default.
- W9104927 hasConceptScore W9104927C2777956040 @default.
- W9104927 hasConceptScore W9104927C2779689624 @default.
- W9104927 hasConceptScore W9104927C2780664492 @default.
- W9104927 hasConceptScore W9104927C55493867 @default.
- W9104927 hasConceptScore W9104927C71924100 @default.
- W9104927 hasConceptScore W9104927C86803240 @default.
- W9104927 hasConceptScore W9104927C98274493 @default.
- W9104927 hasIssue "1_Supplement" @default.
- W9104927 hasLocation W91049271 @default.
- W9104927 hasOpenAccess W9104927 @default.
- W9104927 hasPrimaryLocation W91049271 @default.
- W9104927 hasRelatedWork W2032043921 @default.
- W9104927 hasRelatedWork W2045487608 @default.
- W9104927 hasRelatedWork W2048022180 @default.
- W9104927 hasRelatedWork W2053177676 @default.
- W9104927 hasRelatedWork W2071602877 @default.
- W9104927 hasRelatedWork W2089879001 @default.
- W9104927 hasRelatedWork W2090678893 @default.
- W9104927 hasRelatedWork W2103025395 @default.
- W9104927 hasRelatedWork W2152113795 @default.
- W9104927 hasRelatedWork W2472394872 @default.
- W9104927 hasVolume "184" @default.
- W9104927 isParatext "false" @default.
- W9104927 isRetracted "false" @default.
- W9104927 magId "9104927" @default.
- W9104927 workType "article" @default.