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- W91053357 abstract "Introduction: When 3 kDa soluble fluorescent dextranor 40 kDa ovalbumin are injected into the mouse striatum,they spread diffusely through the brain parenchymaand rapidly drain out of the brain alongperivascular basement membranes surrounding capillariesand arteries. In the present study we test thehypothesis that immune complexes formed in the braindisrupt the perivascular drainage of solutes. Material and methods: Immune complexes were formedin the brain by actively immunizing mice against ovalbuminand then injecting ovalbumin intracerebrally.Twenty-four hours later dextran tracer was injectedinto the brain at the same site and animals killed5 min and 3 h later. Results: At 5 min and 3 h after injection of the dextrantracer into the brains of immunized mice, immunecomplexes were located in the walls of arteries (asshown by Teeling et al. at this meeting). There was asignificant reduction in the diffuse spread of dextran inthe brain parenchyma and significantly fewer capillaryand artery basement membranes contained dextran at5 min when compared with the nonimmunized controls.Instead, the dextran tracer was concentrated inthe perivenous spaces that were occupied by inflammatorycells. Conclusions: The results suggest that immune complexesdisrupt and alter the pattern of perivasculardrainage of solutes from the brain. This may havesignificance for inflammatory diseases in the brainand for immunotherapy for Alzheimer’s disease inwhich immune complexes may form and furtherblock the perivascular drainage pathways that isalready compromised by the deposition of amyloidbeta.This work is supported by the AlzheimerResearch Trust." @default.
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- W91053357 date "2008-01-04" @default.
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- W91053357 title "Immune complexes formed in the brain disrupt the perivascular drainage of solutes and interstitial fluid: significance for immunotherapy in Alzheimer's disease" @default.
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