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- W91079172 abstract "Sodium intake occurs either as a spontaneous or an induced behavior, which is increased by repeated episodes of water deprivation followed by partial rehydration (WD-PR). In this work, we quantified transcripts related to RAS in the hypothalamus of rats that had a history of WD-PR. Adult male Holtzman rats (n=6–12/group) had water and 0.3 M NaCl measured daily. The animals were submitted to one or three episodes of WD-PR, with 7-day interval among the three episodes. The animals were sacrificed at the end of the 1st or 3rd WD-PR (dehydrated) or four days after none, 1st, or 3rd WD-PR (hydrated). The hypothalamus was dissected and level of mRNA for components of the RAS was determined by qRT-PCR. Dehydrated animals had increased hypothalamic transcripts of angiotensinogen, aminopeptidase N, ANG II receptor type-1-associated protein, ANG receptor like-1 or apelin receptor by 43%, 60%, 36%, and 159%, respectively, in the 3rd versus 1st WD-PR. There was no difference in the hypothalamic mRNA content of RAS among hydrated animals. The 0.3 M NaCl intake was enhanced in the 3rd compared to the 1st sodium appetite test in a distinct group. These data suggest that enhancement in the induced sodium intake is associated with alterations in gene expression related to RAS in the hypothalamus. Therefore, hypothalamic RAS may play a role in the long-term changes of sodium appetite. Research supported by CNPq and FAPESP." @default.
- W91079172 created "2016-06-24" @default.
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- W91079172 date "2010-04-01" @default.
- W91079172 modified "2023-10-05" @default.
- W91079172 title "Salt intake sensitization and hypothalamic expression of genes related to the renin‐angiotensin system" @default.
- W91079172 doi "https://doi.org/10.1096/fasebj.24.1_supplement.1025.5" @default.
- W91079172 hasPublicationYear "2010" @default.
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