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- W91086989 abstract "Viral vector gene therapy provides a promising alternative therapy for intractable focal epilepsies. Our studies have established a novel gene therapy platform that not only has proven quite effective against seizure activity, but also circumvents several therapeutic liabilities. AAV-mediated expression and constitutive secretion of galanin, NPY, or NPY(13–36) markedly suppresses limbic seizure activity. However, further advances are necessary to optimize this therapy. To this end, we are using the techniques of DNA shuffling and directed evolution to identify optimal AAV vectors for anti-seizure gene therapy." @default.
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- W91086989 date "2009-01-01" @default.
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- W91086989 title "TREATMENTS (NON-ANTIEPILEPTIC DRUGS) | Viral Vector Approaches for Antiepileptic Gene Therapy" @default.
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- W91086989 doi "https://doi.org/10.1016/b978-012373961-2.00295-2" @default.
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