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• W911753804 abstract "The epididymis-specific adhesion G protein-coupled receptor (aGPCR) GPR64/ADGRG2 has been shown to be a key-player in the male reproductive system. As its disruption leads to infertility, GPR64 has drawn attention as potential target for male fertility control or improvement. Like the majority of aGPCRs GPR64 is an orphan receptor regarding its endogenous agonist and signal transduction. In this study we examined the G protein-coupling abilities of GPR64 and showed that it is activated through a tethered agonist sequence, which we have previously identified as the Stachel sequence. Synthetic peptides derived from the Stachel region can activate the receptor, opening for the first time the possibility to externally manipulate the receptor activity." @default.
• W911753804 created "2016-06-24" @default.
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• W911753804 date "2015-08-01" @default.
• W911753804 modified "2023-09-30" @default.
• W911753804 title "Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2" @default.
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• W911753804 doi "https://doi.org/10.1016/j.bbrc.2015.07.020" @default.
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