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- W91197329 endingPage "245" @default.
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- W91197329 abstract "This chapter outlines the major accomplishments and recent developments in the area of combinatorial libraries composed of chiral molecules. Examples presented in this chapter largely focus on the process of early drug discovery, with a particular focus on natural product (NP)-like scaffolds and small organic molecules. Accordingly, hit-to-lead finding approaches are the main focus of this study. The topic of combinatorial biocatalysis has also been included in this chapter as it represents a powerful and useful direction in the synthesis of chiral libraries. The aim of this chapter is to provide an up-to-date account of different types of combinatorial libraries, with a specific emphasis on stereochemistry. Treatment of the final molecular topology will be considered at three levels. Depending on the source of chirality, the chiral properties of synthesized molecules are introduced by chiral constituents of the starting building blocks (scaffolds), introduction of chiral substituents, or using a variety of asymmetric chemical transformations. Libraries of compounds bearing a chiral center(s) without any stereochemical assignment will also be considered as part of this chapter." @default.
- W91197329 created "2016-06-24" @default.
- W91197329 creator A5075798389 @default.
- W91197329 creator A5083669141 @default.
- W91197329 date "2012-01-01" @default.
- W91197329 modified "2023-10-16" @default.
- W91197329 title "1.10 Chirality and Combinatorial Libraries for Drug Discovery, an Overview" @default.
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