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- W91232510 abstract "Histone deacetylase inhibitors (HDACi),such as trichostatin A (TSA),can significantly enhance the developmental competence of somatic cell nuclear transfer (SCNT) embryos.The present study was designed to examine the effect of TSA,especially the concentration of TSA and the treat period,on the development of pig SCNT embryos.The reaults showed that the treatment of cloned pig embryos with 40 nmol·L-1 TSA could significantly improve the in vitro blastocyst rate compared with the control group,whereas no significant deference of the blastocyst rate was observed between treatment period of 12 and 24 h.40 nmol·L-1 TSA treated 12 h could enhance the blstocyst rate of porcine SCNT embryos regardless of the difference of donor cells compared with control group,but there was no significant difference of the blastocyst rate between SCNT embryos reconstructed with diffirent donor cells.These results indicated that 40 nmol·L-1 TSA treated 12 or 24 h could enhance the porcine SCNT embryos in vitro development competence." @default.
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- W91232510 date "2011-01-01" @default.
- W91232510 modified "2023-10-07" @default.
- W91232510 title "Effect of TSA concentration and treatment period on in vitro development of pig somatic cell nuclear transfer (SCNT) embryos." @default.
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