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- W91239789 abstract "Micro‐fluidic chips are particularly attractive in biological and life sciences for analytical purposesbecause they provide a convenient small platform for rapid analysis and detection [1]. Usingmicro‐fluidic devices for the determination of ions emerges as a potential solution to some of thechallenges not overtaken by conventional techniques e.g. atomic absorption, inductively‐coupledplasma‐optical emission, mass spectrometry and ion‐selective electrodes [2]. For example, thesedevices can integrate complex sample handling processes, calibration, and detection steps into acompact, portable system. Moreover they require small sample volumes (low μl or nl), consumelittle power, and are easily constructed for multi‐analyte detection, either through multipleparallel fluidic architectures or by using arrays of detection elements.Organic photochromic compounds like spiropyrans are particularly interesting targets for thedevelopment of new approaches to sensing since they offer new routes to multi‐functionalmaterials that take advantage of their photo‐reversible interconversion between twothermodynamically stable states (a spiropyran (SP) form, and a merocyanine (MC) form), whichhave dramatically different charge, polarity and molecular conformations. Furthermore, they canbe easily incorporated into membranes for improved robustness and ease of handling [3], butfrom our perspective, most interesting of all, they have metal ion‐binding and molecularrecognition properties which are only manifested by the MC form. Based on the coordinationinducedphotochromism characteristic of the MC form, spiropyrans have been employed asmolecular probes for metal ions and organic molecules [4].In this abstract, we show how through integrating the beneficial characteristics of micro‐fluidicdevices and spiropyrans photoswitches, a simple and very innovative chip configured as an on‐linemetal ion sensor array can be realised (Figure 1). The micro‐fluidic device consists of fiveindependent 94 μm depth, 150 μm width channels fabricated in polydimethylsiloxane. Thespiropyran 1’‐(3‐carboxypropyl)‐3,3’‐dimethyl‐6‐nitrospiro‐1‐benzopyran‐2,2’‐indoline (SP‐COOH)is immobilised by physical adsorption directly on ozone plasma activated PDMS micro‐channelwalls. When the colourless, inactive, spiropyran coating absorbs UV light it switches to the highlycoloured merocyanine form (MC‐COOH), which also has an active binding site for certain metalions. Therefore metal ion uptake can be triggered using UV light and subsequently reversed ondemand by shining white light on the coloured complex, which regenerates the inactive spiropyranform, and releases the metal ion. When stock solutions of several metal ions (Ca2+, Zn2+, Hg2+, Cu2+,Co2+) are pumped independently through the five channels, different optical responses wereobserved for each metal (Figure 2), (i.e. complex formation with metal ions is associated withcharacteristic shifts in the visible spectrum), and the platform can therefore be regarded as amicro‐structured device for online multi‐component monitoring of metal cations." @default.
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- W91239789 date "2009-01-01" @default.
- W91239789 modified "2023-10-17" @default.
- W91239789 title "Spiropyran modified PDMS micro-fluidic chip device for photonically controlled sensor array detection of metal ions" @default.
- W91239789 hasPublicationYear "2009" @default.
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