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• W912464554 abstract "Based on a putative binding mode of quizartinib (AC220, 1), a potent FMS-like tyrosine kinase 3 (FLT3) inhibitor in Phase III clinical development, we have designed de novo a simpler aminopyridine-based hinge binding motif. Further optimization focusing on maximizing in vivo efficacy and minimizing CYP3A4 time-dependent inhibition resulted in a highly efficacious compound (6s) in tumor xenograft model for further preclinical development." @default.
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• W912464554 date "2015-09-01" @default.
• W912464554 modified "2023-09-27" @default.
• W912464554 title "Discovery and optimization of a highly efficacious class of 5-aryl-2-aminopyridines as FMS-like tyrosine kinase 3 (FLT3) inhibitors" @default.
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• W912464554 doi "https://doi.org/10.1016/j.bmcl.2015.07.023" @default.
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