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- W91271122 abstract "Publisher Summary This chapter discusses a study to examine the learning and exploratory behavior of rats with deprivation catecholaminergic brain systems activity induced by 6-OHDA. The experiments were carried out on 142 male Wistar rats. Chronic CA-deprivation was caused by neonatal s.c injections daily of 6-OHDA to animals during the first three days after the birth in doses 100 mg/kg. Acute CA-deprivation was reached by the single bilateral intraventricular administration of 6-OHDA to adult animals in doses 150 μg. The behavior of all animals was studied at the age 25 and 90 days. In different experiments, the exploratory activity of animals in open field, learning with the emotionally different reinforcement, and reaction of frustration were investigated. Active conditioned avoidance reflex was a model of learning with the emotionally negative reinforcement. The successive double-sided alternation of runs to the feeding place was a model of learning with the emotionally positive reinforcement. The experiments with the frustration were carried out in the special chamber subdivided into three parts with photoelement registrations of the speed of running to the feeding place. Biochemical analysis showed the long lasting decrease of cortical NA and DA levels in the 6-OHDA treated animals in both the cases, while serotonin level was unchanged." @default.
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- W91271122 date "1986-01-01" @default.
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- W91271122 title "The Learning and Exploratory Behaviour of Rats with Deprivation Catecholaminergic Brain Systems Activity Induced by 6-OHDA" @default.
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- W91271122 doi "https://doi.org/10.1016/b978-0-08-034186-6.50059-1" @default.
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