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- W9131134 abstract "This chapter discusses tests used to diagnose disorders related to hypothalamic–pituitary–adrenal secretions. Dynamic testing procedures employed in the estimation of adrenal hypo- or hyperfunction are of three types—stimulation tests, suppression test, and repeated sampling for cortisol and/or adrenocorticotropic hormone (ACTH). Tests may stimulate the secretion of the adrenal cortex by exogenous administration of ACTH or stimulate endogenous secretion of ACTH following the administration of insulin or metyrapone. Suppression tests employ the administration of dexamethasone, although in unusual circumstances, cortisol may be employed to suppress ACTH secretion. Stimulation tests are utilized chiefly for the demonstration of normal adrenal reserve, thus indicating that there is sufficient adrenal tissue present for increased cortisol secretion to occur following ACTH administration. These tests are, thus, most useful in the demonstration of adrenal insufficiency but have also been found to have some application to the diagnosis of adrenal hyperfunction, particularly in the demonstration of partial enzyme deficiencies of congenital adrenal hyperplasia. A hyperactive response is characteristic of pituitary dependent Cushing's disease and lack of response is present in many but not all cortisol-secreting adrenal tumors." @default.
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- W9131134 date "1984-01-01" @default.
- W9131134 modified "2023-09-25" @default.
- W9131134 title "Hypothalamic-Pituitary-Adrenal Axis" @default.
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- W9131134 doi "https://doi.org/10.1016/b978-0-407-00346-0.50044-1" @default.
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