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- W914352246 abstract "目的：探讨检测抗核抗体谱ANA,抗ds-DNA及抗ENA对自身免疫性疾病的应用价值。方法：对77例已确诊为自身免疫疾病患者和53例正常体检者的血清进行ANA、抗ds-DNA及ENA多肽抗体的检测,ANA用生物薄片间接免疫荧光法、抗ds-DNA用绿蝇短膜虫间接免疫荧光法,抗ENA用斑点法进行测定。结果：自身免疫性疾病组与正常对照相比有显著性差异（P〈0.05）,其中ANA阳性率为74%;抗ds-DNA阳性率为53.2%;抗ENA阳性率为68.8%;抗ds-DNA对SLE阳性率为88.9%,抗ENA谱对鉴别病种意义很大,其中抗Sm对SLE阳性率为42.2%,抗SS-A对SS阳性率为40%。结论：ANA是自身免疫性疾病重要的一类抗体,为非特异性抗体,可作为初筛指标。抗ds-DNA、抗Sm为诊断SLE的特异性指标,抗ds-DNA可作为SLE治疗和监测的指标,抗ENA谱可用于鉴别病种.三种抗体联合检测和对照分析,可用于自身免疫疾病的诊断及疗效观察。" @default.
- W914352246 created "2016-06-24" @default.
- W914352246 creator A5019371318 @default.
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- W914352246 creator A5070613801 @default.
- W914352246 date "2007-12-05" @default.
- W914352246 modified "2023-09-23" @default.
- W914352246 title "ANA、抗ds-DNA及ENA多肽抗体对自身免疫性疾病的检测" @default.
- W914352246 hasPublicationYear "2007" @default.
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