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- W91463629 abstract "This chapter discusses the chemical structure, physical functions, and metabolism of glycosphingolipids. Neutral glycosphingolipids based on glucocerebrosides are in higher concentrations in non-neuronal tissue than in the neuronal tissue. Galactocerebroside and sulfatides constitute a significant portion of brain glycosphingolipid, especially in myelin sheath and white matter. Cerebrosides, sphingomyelin, and sulfatide form a significant portion of the lipids of myelin sheath for which several structural models have been proposed, showing the arrangement hydrophobic and hydrophilic groups of constituent lipids and proteins. The chapter further discusses the role of gangliosides in the transmission of nerve impulses. Both gangliosides and neutral glycosphingolipids have antigenic properties; however, the latter are known to be more effective in raising antibodies. Metabolism of sphingolipids was primarily generated by attempts to understand the biochemistry and genetics of inborn errors of metabolism in which one or more glycosphingolipids are stored. Both neutral and sialic acid-containing oligoglycosyl ceramides are degraded by a stepwise removal of terminal sugar residues leading finally to the ceramide. The last sialic acid residue of gangliosides is not cleaved by neuraminidase until it becomes the terminal moiety as a result of the cleavage of other monosaccharides." @default.
- W91463629 created "2016-06-24" @default.
- W91463629 creator A5021056534 @default.
- W91463629 creator A5064352695 @default.
- W91463629 date "1980-01-01" @default.
- W91463629 modified "2023-09-23" @default.
- W91463629 title "STRUCTURE, FUNCTION AND METABOLISM OF GLYCOSPHINGOLIPIDS" @default.
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