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- W91542488 abstract "TO ThE EDiTOR: t amoxifen is an estrogen receptor modulator that is used for the treatment of hormone receptor positive breast cancer. As a prodrug, treatment efficacy may be mediated by 2 active metabolites: 4-hydroxytamoxifen (4-OH-TAM) and 4-hydroxy-Ndesmethyltamoxifen (endoxifen). These metabolites have at least 100-fold higher potency than the parent drug, and in vitro studies have demonstrated that cytochrome P450 2D6 (CYP2D6) is responsible for tamoxifen metabolism. There are reports that patients who are CYP2D6 poor metabolizers have a higher risk of relapse and lower incidence of hot flashes with tamoxifen treatment. This is in part because of lower levels of endoxifen. Depressive symptoms are a frequent complication of breast cancer and many patients are treated with selective serotonin reuptake inhibitors (SSRIs). Moreover, SSRIs also are used to treat hot flashes, a common side effect of tamoxifen. The SSRIs paroxetine and fluoxetine are considered strong CYP2D6 inhibitors. The inhibition of CYP2D6 may decrease tamoxifen metabolites and may adversely affect the efficacy of breast cancer treatment. CLiniCaL Vignette" @default.
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- W91542488 date "2011-05-01" @default.
- W91542488 modified "2023-09-23" @default.
- W91542488 title "Tamoxifen-SSRIs interaction: clinical manifestations of inhibition and lack of inhibition of CYP2D6." @default.
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