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- W915577692 abstract "DDB2 is a tumor-inhibiting factor not only involved a major DNA repair mechanism in the Nucleotide Excision Repair (NER), but also correlated with cell apoptosis in the DNA damage response pathway. During serum-starvation, we noted that the translation levels of DDB2 were increased. To evaluate whether the 5′-UTR of DDB2 harbors an IRES element, we used a bicistronic luciferase plasmid with the 5′-UTR of DDB2 inserted between two cistron coding regions. We found that DDB2 5′-UTR could initiate the downstream reporter, demonstrating that the 5′-UTR of DDB2 contained an IRES. The 5′-UTR of DDB2 was predicted into a relatively stable secondary structure by the Mfold program. We deleted the stem-loops in turn to analyze the core part of IRES and found that full length of the 5′-UTR was significant for the IRES activity. Furthermore, our data demonstrated that the DDB2 IRES activity was promoted during stress conditions. These results reveal a novel mechanism contributing to DDB2 expression." @default.
- W915577692 created "2016-06-24" @default.
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- W915577692 date "2015-11-01" @default.
- W915577692 modified "2023-10-10" @default.
- W915577692 title "The 5′-UTR of DDB2 harbors an IRES element and upregulates translation during stress conditions" @default.
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- W915577692 doi "https://doi.org/10.1016/j.gene.2015.07.032" @default.
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