Matches in SemOpenAlex for { <https://semopenalex.org/work/W91591212> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W91591212 endingPage "63" @default.
- W91591212 startingPage "55" @default.
- W91591212 abstract "Objectives : In this study, we investigated anti-allergic effect of Okbyeongpungsan-Hap-Changijasan (KOB01) in allergic rhinitis(AR) experimental animals and mast cells. Methods : The potential anti-allergic effect of KOB01 was investigated in a rat model of compound 48/80-induced systemic anaphylactic shock and a mouse of ovalbumin(OVA)-induced AR, and human mast cell line, HMC-1 culture. Each animals were divided into four groups: normal, control, KOB01-treated(100 and 200 mg/kg) and anti-histamine drug, dosodium cromoglycate (DSCG)-treated(50 mg/kg). Animals were orally treated with KOB01 and DSCG and intraperitoneally injected with compound 48/80() or sensitized with 0.1% OVA. The mortality and serum histamine levels were measured in compound 48/80-induced anaphylatic rats. The histological changes in nasal mucosa were investigated in OVA-induced AR mice. Also, mast cell degranulation was observed in compound 48/80-stimulated HMC-1 cells. Results : KOB01 increased mortality and significantly decreased serum histamine levels in compound 48/80-induced anaphylatic rats. The abnormal histological changes such as expansion of grandular cells and hypertrophy of epithelium in nasal mucosa of OVA-induced AR mice was improved by KOB01 treatment nearby a normal group. Therefore, KOB01 inhibited compound 48/80-induced degranulation in HMC-1 cells. Conclusions : These results indicate that KOB01 decrease allergic response through suppressing the mast cell activation in AR and suggest a potential role for KOB01 as a source of anti-allergic agents for use in allergic disorders including of AR." @default.
- W91591212 created "2016-06-24" @default.
- W91591212 creator A5012517682 @default.
- W91591212 creator A5018228594 @default.
- W91591212 date "2010-01-01" @default.
- W91591212 modified "2023-09-24" @default.
- W91591212 title "Anti-allergic effect of Okbyungpoongsan-Hap-Changijasan" @default.
- W91591212 cites W1779098122 @default.
- W91591212 cites W1975173921 @default.
- W91591212 cites W2099005543 @default.
- W91591212 cites W37436426 @default.
- W91591212 doi "https://doi.org/10.6116/kjh.2010.25.2.055" @default.
- W91591212 hasPublicationYear "2010" @default.
- W91591212 type Work @default.
- W91591212 sameAs 91591212 @default.
- W91591212 citedByCount "2" @default.
- W91591212 countsByYear W915912122012 @default.
- W91591212 crossrefType "journal-article" @default.
- W91591212 hasAuthorship W91591212A5012517682 @default.
- W91591212 hasAuthorship W91591212A5018228594 @default.
- W91591212 hasConcept C1122143 @default.
- W91591212 hasConcept C126322002 @default.
- W91591212 hasConcept C134018914 @default.
- W91591212 hasConcept C141105273 @default.
- W91591212 hasConcept C159654299 @default.
- W91591212 hasConcept C170493617 @default.
- W91591212 hasConcept C185592680 @default.
- W91591212 hasConcept C203014093 @default.
- W91591212 hasConcept C207480886 @default.
- W91591212 hasConcept C2776946954 @default.
- W91591212 hasConcept C2776953665 @default.
- W91591212 hasConcept C2779726688 @default.
- W91591212 hasConcept C2781082844 @default.
- W91591212 hasConcept C2781406822 @default.
- W91591212 hasConcept C49802076 @default.
- W91591212 hasConcept C59377437 @default.
- W91591212 hasConcept C71924100 @default.
- W91591212 hasConcept C8891405 @default.
- W91591212 hasConcept C98274493 @default.
- W91591212 hasConceptScore W91591212C1122143 @default.
- W91591212 hasConceptScore W91591212C126322002 @default.
- W91591212 hasConceptScore W91591212C134018914 @default.
- W91591212 hasConceptScore W91591212C141105273 @default.
- W91591212 hasConceptScore W91591212C159654299 @default.
- W91591212 hasConceptScore W91591212C170493617 @default.
- W91591212 hasConceptScore W91591212C185592680 @default.
- W91591212 hasConceptScore W91591212C203014093 @default.
- W91591212 hasConceptScore W91591212C207480886 @default.
- W91591212 hasConceptScore W91591212C2776946954 @default.
- W91591212 hasConceptScore W91591212C2776953665 @default.
- W91591212 hasConceptScore W91591212C2779726688 @default.
- W91591212 hasConceptScore W91591212C2781082844 @default.
- W91591212 hasConceptScore W91591212C2781406822 @default.
- W91591212 hasConceptScore W91591212C49802076 @default.
- W91591212 hasConceptScore W91591212C59377437 @default.
- W91591212 hasConceptScore W91591212C71924100 @default.
- W91591212 hasConceptScore W91591212C8891405 @default.
- W91591212 hasConceptScore W91591212C98274493 @default.
- W91591212 hasIssue "2" @default.
- W91591212 hasLocation W915912121 @default.
- W91591212 hasOpenAccess W91591212 @default.
- W91591212 hasPrimaryLocation W915912121 @default.
- W91591212 hasRelatedWork W1575707891 @default.
- W91591212 hasRelatedWork W1594012971 @default.
- W91591212 hasRelatedWork W1978727247 @default.
- W91591212 hasRelatedWork W1995221097 @default.
- W91591212 hasRelatedWork W2002479175 @default.
- W91591212 hasRelatedWork W2007746746 @default.
- W91591212 hasRelatedWork W2065915431 @default.
- W91591212 hasRelatedWork W2067644354 @default.
- W91591212 hasRelatedWork W2068691423 @default.
- W91591212 hasRelatedWork W2161099629 @default.
- W91591212 hasRelatedWork W2263707459 @default.
- W91591212 hasRelatedWork W2360283558 @default.
- W91591212 hasRelatedWork W2370105373 @default.
- W91591212 hasRelatedWork W2430991179 @default.
- W91591212 hasRelatedWork W2469149650 @default.
- W91591212 hasRelatedWork W3005553289 @default.
- W91591212 hasRelatedWork W3086109232 @default.
- W91591212 hasRelatedWork W3183344044 @default.
- W91591212 hasRelatedWork W765509711 @default.
- W91591212 hasRelatedWork W768447037 @default.
- W91591212 hasVolume "25" @default.
- W91591212 isParatext "false" @default.
- W91591212 isRetracted "false" @default.
- W91591212 magId "91591212" @default.
- W91591212 workType "article" @default.