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- W916005301 abstract "目的研究乳腺浸润性导管癌、乳腺良性病变组织中垂体瘤转化基因（PTTG）,基质金属蛋白酶-14（MMP-14）和血管内皮生长因子-C（VEGF-C）的表达水平,探讨其临床病理意义。方法 40例乳腺浸润性导管癌、20例乳腺良性病变手术切除标本常规石蜡包埋切片,PTTG、MMP-14和VEGF-C染色方法为免疫组化SP法。结果乳腺浸润性导管癌PTTG、VEGF-C和MMP-14表达阳性率（75.0%、85.0%和77.5%）明显高于乳腺良性病变（20.0%、30.0%和25.0%,P〈0.01）,有淋巴结转移病例PTTG、VEGF-C和MMP-14表达阳性率明显高于无淋巴结转移病例（P〈0.01）,而在不同年龄、肿瘤大小、分化程度组间差别无统计学意义（P〉0.05）。乳腺浸润性导管癌中PTTG与VEGF-C和MMP-14表达呈高度一致性（r=0.586,0.657,P〈0.01）,VEGF-C与MMP-14表达亦呈高度一致性（r=0.649,P〈0.01）。结论 PTTG、VEGF-C和MMP-14的表达可能是反映乳腺浸润性导管癌发生、发展、生物学行为及预后的重要生物学指标,三者有望成为乳腺癌抗淋巴管治疗的新靶点。" @default.
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- W916005301 date "2011-01-01" @default.
- W916005301 modified "2023-09-23" @default.
- W916005301 title "乳腺良恶性病变PTTG、VEGF-C和MMP-14表达及临床病理意义" @default.
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