Matches in SemOpenAlex for { <https://semopenalex.org/work/W9160762> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W9160762 endingPage "97" @default.
- W9160762 startingPage "787" @default.
- W9160762 abstract "Neuropsychiatric symptoms are commonly related to interferon alpha treatment. The paper summarises the current knowledge about their aetiology, course, and treatment. Interferon alpha is a cytokine with antiviral and antineoplasmatic activity. It is commonly used in the treatment of chronic hepatitis C and B, malignant melanoma, Kaposi sarcoma, renal cancers, and some haematological malignancies. Treatment with interferon alpha is associated with depressive symptoms, cognitive disturbances, chronic fatigue syndrome, dysphoria, anxiety symptoms, anorexia, mania and psychotic states. Up to a half of the patients need psychiatric consultations, 10-25% of them need psychiatric treatment. Neuropsychiatric symptoms are the results of direct affection of CNS by interferon and induced cytokines. They increase hypothalamic-pituitary-adrenal (HPA) activity, alter thyroid function and lead to a behavioural syndrome called 'sickness behaviour'. Moreover interferon induces the activity of 2, 3 indoloamine dioxygenase, the enzyme which converts tryptophan into kynurenine, leads to a reduced level of tryptophan, and thus to a reduced level of central serotonin and to an increased level of neurotoxic kynurenine metabolites. Interferon also affects central opioid receptors and changes dopaminergic and noradrenergic neurotransmission. Serotonin selective reuptake inhibitors (SSRI), other antidepressants i.e. nortriptyline, benzodiazepines, naltrexone, and neuroleptics (for maniac and psychotic states) are used to treat interferon associated psychiatric symptoms. Psychological therapy may also be useful, as well as psychoeducation and behavioural interventions." @default.
- W9160762 created "2016-06-24" @default.
- W9160762 creator A5010916195 @default.
- W9160762 creator A5025181350 @default.
- W9160762 creator A5038712199 @default.
- W9160762 creator A5041552894 @default.
- W9160762 creator A5044074957 @default.
- W9160762 creator A5065770877 @default.
- W9160762 date "2006-10-31" @default.
- W9160762 modified "2023-09-23" @default.
- W9160762 title "[Neuropsychiatric symptoms related to interferon alpha]." @default.
- W9160762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17068950" @default.
- W9160762 hasPublicationYear "2006" @default.
- W9160762 type Work @default.
- W9160762 sameAs 9160762 @default.
- W9160762 citedByCount "3" @default.
- W9160762 countsByYear W91607622012 @default.
- W9160762 countsByYear W91607622014 @default.
- W9160762 crossrefType "journal-article" @default.
- W9160762 hasAuthorship W9160762A5010916195 @default.
- W9160762 hasAuthorship W9160762A5025181350 @default.
- W9160762 hasAuthorship W9160762A5038712199 @default.
- W9160762 hasAuthorship W9160762A5041552894 @default.
- W9160762 hasAuthorship W9160762A5044074957 @default.
- W9160762 hasAuthorship W9160762A5065770877 @default.
- W9160762 hasConcept C103709681 @default.
- W9160762 hasConcept C118552586 @default.
- W9160762 hasConcept C126322002 @default.
- W9160762 hasConcept C15744967 @default.
- W9160762 hasConcept C203014093 @default.
- W9160762 hasConcept C2776174506 @default.
- W9160762 hasConcept C2776178377 @default.
- W9160762 hasConcept C2776809841 @default.
- W9160762 hasConcept C2780733359 @default.
- W9160762 hasConcept C2909179924 @default.
- W9160762 hasConcept C71924100 @default.
- W9160762 hasConceptScore W9160762C103709681 @default.
- W9160762 hasConceptScore W9160762C118552586 @default.
- W9160762 hasConceptScore W9160762C126322002 @default.
- W9160762 hasConceptScore W9160762C15744967 @default.
- W9160762 hasConceptScore W9160762C203014093 @default.
- W9160762 hasConceptScore W9160762C2776174506 @default.
- W9160762 hasConceptScore W9160762C2776178377 @default.
- W9160762 hasConceptScore W9160762C2776809841 @default.
- W9160762 hasConceptScore W9160762C2780733359 @default.
- W9160762 hasConceptScore W9160762C2909179924 @default.
- W9160762 hasConceptScore W9160762C71924100 @default.
- W9160762 hasIssue "4" @default.
- W9160762 hasLocation W91607621 @default.
- W9160762 hasOpenAccess W9160762 @default.
- W9160762 hasPrimaryLocation W91607621 @default.
- W9160762 hasRelatedWork W130625316 @default.
- W9160762 hasRelatedWork W1845758349 @default.
- W9160762 hasRelatedWork W1975952472 @default.
- W9160762 hasRelatedWork W2018436076 @default.
- W9160762 hasRelatedWork W2038429653 @default.
- W9160762 hasRelatedWork W2057670077 @default.
- W9160762 hasRelatedWork W2063139961 @default.
- W9160762 hasRelatedWork W2080812988 @default.
- W9160762 hasRelatedWork W2085486223 @default.
- W9160762 hasRelatedWork W2119526257 @default.
- W9160762 hasRelatedWork W2157072257 @default.
- W9160762 hasRelatedWork W2199941754 @default.
- W9160762 hasRelatedWork W2304605006 @default.
- W9160762 hasRelatedWork W2604746879 @default.
- W9160762 hasRelatedWork W2730275538 @default.
- W9160762 hasRelatedWork W2766064676 @default.
- W9160762 hasRelatedWork W2888778117 @default.
- W9160762 hasRelatedWork W2909679535 @default.
- W9160762 hasRelatedWork W322736282 @default.
- W9160762 hasRelatedWork W2183666419 @default.
- W9160762 hasVolume "40" @default.
- W9160762 isParatext "false" @default.
- W9160762 isRetracted "false" @default.
- W9160762 magId "9160762" @default.
- W9160762 workType "article" @default.