Matches in SemOpenAlex for { <https://semopenalex.org/work/W917798766> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W917798766 abstract "Renal interstitial fibrosis is characterized by renal fibroblast proliferation. This process involves renal tubular epithelial cells adopting a fibroblast morphology through epithelial-to-mesenchymal transition (EMT). EMT produces phenotypic changes such as epithelial cell adherins junction loss and de novo α-smooth muscle actin (SMA) expression. TGF-ß1 has been shown to stimulate EMT. Identifying agents that inhibit TGF-ß1 induced EMT may prevent patient progression towards chronic renal failure (CRF). Previous work from our laboratory has shown that 4-phenylbuterate (4-PBA), a histone deacetylase inhibitor (HDACi), inhibited EMT. In this study, we hypothesized that a broad spectrum HDACi, vorinastat, would inhibit TGF-ß1 induced EMT and apoptosis in human proximal tubular epithelium (hPTE). We tested vorinastat and 4-PBA on TGF-ß1 induced EMT in hPTE. TGF-ß1 induced EMT was inhibited by both 1mM 4-PBA and 5μM vorinastat as shown by cadherin junction preservation and reduced de novo α-SMA expression. Vorinastat was also shown to prevent TGF-ß1-induced decrease of E-cadherin and increase of type I collagen transcript levels. Further, 4-PBA and vorinastat inhibited TGF-ß1 induced apoptosis in hPTE. These findings suggest that HDACi prevent EMT and apoptosis induced by TGFß1 and may reduce the progression of patients with chronic kidney disease towards CRF. Funding, CIHR OSO-115895." @default.
- W917798766 created "2016-06-24" @default.
- W917798766 creator A5011679936 @default.
- W917798766 creator A5053126987 @default.
- W917798766 creator A5086950143 @default.
- W917798766 date "2013-04-01" @default.
- W917798766 modified "2023-09-23" @default.
- W917798766 title "The HDAC inhibitor, vorinastat, prevents TGF‐β1 induced EMT and apoptosis in human renal proximal tubular cells" @default.
- W917798766 doi "https://doi.org/10.1096/fasebj.27.1_supplement.705.13" @default.
- W917798766 hasPublicationYear "2013" @default.
- W917798766 type Work @default.
- W917798766 sameAs 917798766 @default.
- W917798766 citedByCount "0" @default.
- W917798766 crossrefType "journal-article" @default.
- W917798766 hasAuthorship W917798766A5011679936 @default.
- W917798766 hasAuthorship W917798766A5053126987 @default.
- W917798766 hasAuthorship W917798766A5086950143 @default.
- W917798766 hasConcept C104317684 @default.
- W917798766 hasConcept C118131993 @default.
- W917798766 hasConcept C121608353 @default.
- W917798766 hasConcept C126322002 @default.
- W917798766 hasConcept C147447768 @default.
- W917798766 hasConcept C1491633281 @default.
- W917798766 hasConcept C149402561 @default.
- W917798766 hasConcept C185592680 @default.
- W917798766 hasConcept C190283241 @default.
- W917798766 hasConcept C202751555 @default.
- W917798766 hasConcept C204232928 @default.
- W917798766 hasConcept C2776202225 @default.
- W917798766 hasConcept C2778305200 @default.
- W917798766 hasConcept C2779013556 @default.
- W917798766 hasConcept C2780381497 @default.
- W917798766 hasConcept C502942594 @default.
- W917798766 hasConcept C55493867 @default.
- W917798766 hasConcept C64927066 @default.
- W917798766 hasConcept C71924100 @default.
- W917798766 hasConcept C76419328 @default.
- W917798766 hasConcept C86803240 @default.
- W917798766 hasConcept C95444343 @default.
- W917798766 hasConceptScore W917798766C104317684 @default.
- W917798766 hasConceptScore W917798766C118131993 @default.
- W917798766 hasConceptScore W917798766C121608353 @default.
- W917798766 hasConceptScore W917798766C126322002 @default.
- W917798766 hasConceptScore W917798766C147447768 @default.
- W917798766 hasConceptScore W917798766C1491633281 @default.
- W917798766 hasConceptScore W917798766C149402561 @default.
- W917798766 hasConceptScore W917798766C185592680 @default.
- W917798766 hasConceptScore W917798766C190283241 @default.
- W917798766 hasConceptScore W917798766C202751555 @default.
- W917798766 hasConceptScore W917798766C204232928 @default.
- W917798766 hasConceptScore W917798766C2776202225 @default.
- W917798766 hasConceptScore W917798766C2778305200 @default.
- W917798766 hasConceptScore W917798766C2779013556 @default.
- W917798766 hasConceptScore W917798766C2780381497 @default.
- W917798766 hasConceptScore W917798766C502942594 @default.
- W917798766 hasConceptScore W917798766C55493867 @default.
- W917798766 hasConceptScore W917798766C64927066 @default.
- W917798766 hasConceptScore W917798766C71924100 @default.
- W917798766 hasConceptScore W917798766C76419328 @default.
- W917798766 hasConceptScore W917798766C86803240 @default.
- W917798766 hasConceptScore W917798766C95444343 @default.
- W917798766 hasIssue "S1" @default.
- W917798766 hasLocation W9177987661 @default.
- W917798766 hasOpenAccess W917798766 @default.
- W917798766 hasPrimaryLocation W9177987661 @default.
- W917798766 hasRelatedWork W2039165130 @default.
- W917798766 hasRelatedWork W2063306428 @default.
- W917798766 hasRelatedWork W2094552440 @default.
- W917798766 hasRelatedWork W2125750780 @default.
- W917798766 hasRelatedWork W2353959944 @default.
- W917798766 hasRelatedWork W2791543886 @default.
- W917798766 hasRelatedWork W2804256761 @default.
- W917798766 hasRelatedWork W2946026584 @default.
- W917798766 hasRelatedWork W3029812335 @default.
- W917798766 hasRelatedWork W3030447506 @default.
- W917798766 hasVolume "27" @default.
- W917798766 isParatext "false" @default.
- W917798766 isRetracted "false" @default.
- W917798766 magId "917798766" @default.
- W917798766 workType "article" @default.