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- W91799800 abstract "The use of amphiphilic block copolymers (ABC)s in experimental medicine and pharmaceutical sciences has a long history and is expecting rapid development. Poly(ethylene oxide)–block–poly(amino acid) and poly(ethylene oxide)–block–polyesters represented the most important two types of ABCs for development of nanocarriers for drug/gene delivery. In this chapter, we provided an update on several chemical strategies used to enhance the properties of nanoscopic core/shell structures formed from self assembly of ABCs, namely polymeric micelles. Versatility of polymer chemistry in ABCs provides unique opportunities for tailoring polymeric micelles for optimal properties in gene and drug delivery. Chemical modification of the polymer structure in the micellar core through introduction of hydrophobic or charged moieties, conjugation of drug compatible groups, core cross-linking has led to enhanced stability for the micellar structure and sustained or pH-sensitive drug release. The modification of polymeric micellar surface with specific ligands (carbohydrates, peptides, antibodies) has shown benefits in enhancing the recognition of carrier by selective cells leading to improved drug and gene delivery to the desired targets. Research in drug delivery by polymeric vesicles is still in its infancy, but a similar principle on the importance and benefit of chemical flexibility of block copolymers in improving the delivery properties of polymeric vesicles can also be envisioned. The demanding challenge of the future research in this field is to find the right carrier architecture and optimum polymer chemistry that can improve the delivery of sophisticated and complex therapeutic agents (e.g., poorly soluble drugs, proteins and genes) to their cellular and intracellular targets." @default.
- W91799800 created "2016-06-24" @default.
- W91799800 creator A5014900225 @default.
- W91799800 creator A5036914466 @default.
- W91799800 date "2011-01-01" @default.
- W91799800 modified "2023-09-23" @default.
- W91799800 title "Amphiphilic Block Copolymer Based Nanocarriers for Drug and Gene Delivery" @default.
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