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- W91843090 abstract "This chapter starts with a historical overview, description of sterile filtration applications, and performance requirements. Special attention is paid to the sterilizing final fill application for biotherapeutics with associated regulatory requirements. Sterile filters, their properties, manufacture, retention mechanisms, and economics are described. The chapter then covers how to develop, implement, and validate a sterile filtration process. Methods for filter selection, testing with scaled-down devices, sizing, system design, and operation are included. The use of filter bacterial challenge studies, system sterilization, and integrity testing for validation of the filtration process are covered. The chapter finishes with case studies in several areas the authors felt warranted special consideration." @default.
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- W91843090 date "2013-01-01" @default.
- W91843090 modified "2023-09-25" @default.
- W91843090 title "Sterile Filtration: Principles, Best Practices and New Developments" @default.
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- W91843090 doi "https://doi.org/10.1007/978-1-4614-7978-9_16" @default.
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