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- W918733037 abstract "Objective To explore the reversal effects of levofloxacin on human multi-drug resistance carcinoma cell line A549/ADM and the related mechanisms.Methods The expressions of resistance proteins MRP and P-gp were detected with flow cytometry.The accumulation of ADM in A549/ADM cells was evaluated with flow cytometry.The resistance to chemotherapeutic drugs and the reversal with levofloxacin was evaluated with MTT.Results A549/ADM cells were proved multidrug-resistant.The resistance index of A549/ADM to ADM was 14.29 and the cells showed resistance to DDP,VCR and VP16,but not to 5-FU.Compared with A549 cells,the expressions of P-gp and MRP rise up to 74.8% and 61.2% respectively.With levofloxacin added sensitivity of A549/ADM cells to ADM raised by 2.55 times and accumulation of ADM in A549/ADM cells was significantly increased.Sensitivity to VCR,DDP and VP16 increased 7.38,1.29 and 4.05 times,respectively.Conclusions A549/ADM cells are resistant to clinically common used anti-cancer chemotherapeutic drugs and the resistance might related to P-gp and MRP overexpression.Levofloxacin could reverse partly the MDR of lung adenocarcinoma cell line A549/ADM." @default.
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- W918733037 date "2009-01-01" @default.
- W918733037 modified "2023-09-24" @default.
- W918733037 title "Reverse effect of levofloxacin on lung adenocarcinoma multidrug-resistance cell line A549/ADM." @default.
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