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- W918937935 endingPage "517" @default.
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- W918937935 abstract "The phosphatidylinositol-3-kinase/Akt and the mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in prostate cancer (CaP) and other cancers, and responsible for the survival, metastasis and therapeutic resistance. Recent advances in radiation therapy indicate that activation of this pathway is closely associated with cancer radioresistance, which is a major challenge for the current CaP radiation treatment. Therefore, targeting this pathway by inhibitors to enhance radiosensitivity has great potential for clinical benefits of CaP patients. In this review, we summarize the recent findings in the PI3K/Akt/mTOR pathway in CaP radiotherapy research and discuss the potential use of the PI3K/Akt/mTOR pathway inhibitors as radiosensitizers in the treatment of CaP radioresistance in preclinical studies to explore novel approaches for future clinical trials." @default.
- W918937935 created "2016-06-24" @default.
- W918937935 creator A5000417932 @default.
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- W918937935 creator A5073920233 @default.
- W918937935 creator A5081605114 @default.
- W918937935 creator A5086916480 @default.
- W918937935 date "2015-12-01" @default.
- W918937935 modified "2023-10-17" @default.
- W918937935 title "Targeting PI3K/Akt/mTOR signaling pathway in the treatment of prostate cancer radioresistance" @default.
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