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• W91903332 abstract "Neonatal responses to peripheral cutaneous sensory stimuli appear hyperexcitablecompared to those of the adult, at both behavioural and cellular levels. Little isknown, however, of the mechanisms involved in the maturation of this sensorycircuitry over the postnatal period. I hypothesise that the excitability of neonatalnetworks is due to immature local and descending inhibitory control of spinalcircuits. To test this I have examined the maturation of descending and localinhibitory spinal circuitry using immunohistochemical staining in the dorsal horn, invivo electrophysiological recordings of dorsal horn neurons and stimulation ofbrainstem descending pathways.Firstly, I mapped the development of spinal glycinergic circuitry over the first threepostnatal weeks using immunohistochemical staining of glycinergic terminals andreceptors. Results show a clear shift in expression pattern from deep dorsal hornstaining of both glycinergic terminals and receptors in the neonate, to selectiveexpression in lamina III by the third postnatal week.I then characterised the functional development of glycinergic inhibition of spinalsensory pathways at a cellular level using in vivo extracellular recordings of dorsalhorn neurons in neonatal and adolescent rats in the presence of the glycine receptorantagonist strychnine. Results illustrate an absence of glycinergic inhibition ofsensory stimuli until postnatal day 21 and a facilitatory role of glycine in thetransmission of low-threshold stimuli in the neonatal spinal cord.Finally, I examined the descending influence of the rostroventral medulla on dorsalhorn neuronal activity over postnatal development. Results indicate that the influenceof descending control shifts dramatically from predominantly excitatory in earlydevelopment, to predominantly inhibitory at a later stage in life.In conclusion, there is significant postnatal modulation of segmental and descendinginfluences on spinal networks in the postnatal period, both of which are likely tocontribute to the maturation of cutaneous sensory spinal processing." @default.
• W91903332 created "2016-06-24" @default.
• W91903332 creator A5046087776 @default.
• W91903332 date "2010-07-28" @default.
• W91903332 modified "2023-09-26" @default.
• W91903332 title "The developmental regulation of local and descending control of dorsal horn neurons in the rat" @default.
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