Matches in SemOpenAlex for { <https://semopenalex.org/work/W91909859> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W91909859 endingPage "90" @default.
- W91909859 startingPage "180" @default.
- W91909859 abstract "Peptic ulcer pathophysiology has advanced in several ways during the last years; the following facts has been put forward: a) There has been recognized specific receptors controlling oxyntic cell secretion for histamine, acetylcholine, gastrin and prostaglandins. Agonists and antagonists for the above mentioned receptors has been synthesized. The physiology of the proton-pump located at the luminal side of the mucous membrane has been clarified. This pump is responsible for HCl secretion and can be blocked with omeprazole and trimeprazole. b) There is a comprehensive view of the gastric mucosal barrier, which is important for gastric self-protection, against inner or outer noxious stimuli. The mucosal barrier rupture can be the initial step of some gastroduodenal diseases, so the understanding of its functioning is very important to explain the pathophysiology of peptic ulcer. Finally, some etiopathogenic factors has been proved in the development of peptic ulcer, as Helicobacter pylori, which adheres to gastric cells mucus, damaging the cells after colonization, and producing the rupture of the mucosal barrier; which in turn favours peptic ulcer disease. The use of non-steroidal antiinflammatory drugs (NSAID) can act at several levels; the most important one seems to be the alteration of prostaglandins synthesis and consequent decrease of mucus and bicarbonate secretion. At the same time NSAID can cause antro-pyloric motor disturbances which contributes to peptic ulcer development. The understanding of all those pathophysiological factors has promoted the designs of new pharmacological approaches to the medical treatment of peptic ulcer, so new antiulcer drugs can act at different stages of peptic-acid secretion, like H2-antagonists, proton-pump blockers, cytoprotector drugs and antimicrobial agents for Helicobacter pylori eradication." @default.
- W91909859 created "2016-06-24" @default.
- W91909859 creator A5030656638 @default.
- W91909859 date "1990-04-01" @default.
- W91909859 modified "2023-09-23" @default.
- W91909859 title "[Physiopathological basis for the treatment of peptic ulcer]." @default.
- W91909859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2152274" @default.
- W91909859 hasPublicationYear "1990" @default.
- W91909859 type Work @default.
- W91909859 sameAs 91909859 @default.
- W91909859 citedByCount "0" @default.
- W91909859 crossrefType "journal-article" @default.
- W91909859 hasAuthorship W91909859A5030656638 @default.
- W91909859 hasConcept C10162356 @default.
- W91909859 hasConcept C1122143 @default.
- W91909859 hasConcept C126322002 @default.
- W91909859 hasConcept C18903297 @default.
- W91909859 hasConcept C2776409635 @default.
- W91909859 hasConcept C2776986829 @default.
- W91909859 hasConcept C2777312293 @default.
- W91909859 hasConcept C2777498785 @default.
- W91909859 hasConcept C2779390736 @default.
- W91909859 hasConcept C2780656511 @default.
- W91909859 hasConcept C49039625 @default.
- W91909859 hasConcept C71924100 @default.
- W91909859 hasConcept C86803240 @default.
- W91909859 hasConcept C90924648 @default.
- W91909859 hasConceptScore W91909859C10162356 @default.
- W91909859 hasConceptScore W91909859C1122143 @default.
- W91909859 hasConceptScore W91909859C126322002 @default.
- W91909859 hasConceptScore W91909859C18903297 @default.
- W91909859 hasConceptScore W91909859C2776409635 @default.
- W91909859 hasConceptScore W91909859C2776986829 @default.
- W91909859 hasConceptScore W91909859C2777312293 @default.
- W91909859 hasConceptScore W91909859C2777498785 @default.
- W91909859 hasConceptScore W91909859C2779390736 @default.
- W91909859 hasConceptScore W91909859C2780656511 @default.
- W91909859 hasConceptScore W91909859C49039625 @default.
- W91909859 hasConceptScore W91909859C71924100 @default.
- W91909859 hasConceptScore W91909859C86803240 @default.
- W91909859 hasConceptScore W91909859C90924648 @default.
- W91909859 hasIssue "2" @default.
- W91909859 hasLocation W919098591 @default.
- W91909859 hasOpenAccess W91909859 @default.
- W91909859 hasPrimaryLocation W919098591 @default.
- W91909859 hasRelatedWork W2035019411 @default.
- W91909859 hasRelatedWork W2347675887 @default.
- W91909859 hasRelatedWork W2361050747 @default.
- W91909859 hasRelatedWork W2362251945 @default.
- W91909859 hasRelatedWork W2362347424 @default.
- W91909859 hasRelatedWork W2362641087 @default.
- W91909859 hasRelatedWork W2370481811 @default.
- W91909859 hasRelatedWork W2381655745 @default.
- W91909859 hasRelatedWork W2386461191 @default.
- W91909859 hasRelatedWork W3030036188 @default.
- W91909859 hasVolume "44" @default.
- W91909859 isParatext "false" @default.
- W91909859 isRetracted "false" @default.
- W91909859 magId "91909859" @default.
- W91909859 workType "article" @default.