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• W91911513 abstract "1. Both probiotics and prebiotics are dietary ingredients that modulate the gut microbiota composition and activity. Probiotics are live microbial feed additions, whereas prebiotics are selectively metabolized by beneficial flora components. 2. One of the most common forms of cancer is colorectal. Because the human gut, particularly the colon, harbours an extremely profuse and metabolically active microbiota, there is interest in how the microbial fermentation affects colorectal cancer risk. 3. An important environmental factor that can play a large role in cancers of digestive tract is diet. The principal hypothesis is that fat and meat increase risk and cereals, fruit and vegetables (dietary fibre) decrease risk of cancer. With the current interest in the use of both probiotics and prebiotics to modulate this microbiota, it is feasible that such dietary intervention tools may find use in reducing risk. 4. Probiotics such as bifidobacteria and lactobacilli have many positive effects on the human digestive tract, including the inhibition of pathogens and having anti-cancer activities. However, enterococci, a Gram-positive cocci, and Enterococcus faecalis may have negative effects including the production of hydrogen peroxide and triggering inflammatory bowel disease. 5. Clostridium butyricum, a species belonging to the core Clostridium 1 cluster, has been found to produce butyrate-generating SCFA in the colon. When supplementation of C. butyricum and high-amylase maize starch were fed to rats, it was noted that the colonic pH was lower and became a more favourable condition against cancer. 6. Butyrate, a gut microbial metabolite, has been known to be associated with reduced risk colorectal cancer onset. Colonocytes metabolize butyrate through β-oxidation, enabling it to aid in cell maturation, differentiation and apoptosis. Butyrate is purported as an anti-tumoural agent. It has been shown to induce apoptosis of colon cancer cell lines and inhibit growth in vitro." @default.
• W91911513 created "2016-06-24" @default.
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• W91911513 date "2010-01-01" @default.
• W91911513 modified "2023-09-26" @default.
• W91911513 title "Gut Microbiota, Probiotics, Prebiotics and Colorectal Cancer" @default.
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• W91911513 doi "https://doi.org/10.1007/978-1-60761-627-6_9" @default.
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