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• W919463028 abstract "Due to the application of low-dose computed tomography screening, more and more early-stage lung cancers have been diagnosed. Thus, it is essential to characterize the gene expression profile of early-stage lung cancer to develop potential biomarkers for early diagnosis and therapeutic targets. Here, we analyzed microarray data of 181 early-stage lung cancer patients. By comparing gene expression between different tumor and lymph node metastasis stages, we identified various differentially expressed protein-coding genes and long noncoding RNA (lncRNA) in the comparisons of T2 vs. T2 and N1- vs. N0-stage lung cancer. Functional analyses revealed that these differentially expressed genes were enriched in various tumorigenesis or metastasis-related pathways. Survival analysis indicated that two protein-coding genes, C7 and SCN7A, were significantly associated survival of lung cancer. Notably, a novel lncRNA, LINC00313, was highly expressed in both T2- and N1-stage lung cancers. On the other hand, LINC00313 was also upregulated in lung cancer and metastasized lung cancer tissues, compared with adjacent lung tissues and primary lung cancer tissues. Additionally, higher expression level of LINC00313 indicated poor prognosis of lung cancer (hazard ratio = 0.658). Overall, we characterized the expression profiles of protein-coding genes and lncRNA in early-stage lung cancer and found that LINC00313 could be a biomarker for lung cancer." @default.
• W919463028 created "2016-06-24" @default.
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• W919463028 date "2015-07-16" @default.
• W919463028 modified "2023-10-15" @default.
• W919463028 title "Differentially expressed protein-coding genes and long noncoding RNA in early-stage lung cancer" @default.
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• W919463028 doi "https://doi.org/10.1007/s13277-015-3714-6" @default.
• W919463028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26178480" @default.
• W919463028 hasPublicationYear "2015" @default.
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