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• W91956051 abstract "It is now established that adipose tissue macrophages, which accumulate in obese individuals and rodents, play a key role in the generation of a low-grade, chronic inflammation, as well as the development of steatosis and insulin resistance, when faced with chronic overnutrition. The hypothesis of this dissertation is that other cells of the immune system and inflammatory responses within other insulin sensitive organs are also involved in the metabolic regulation of nutrient utilization. Specifically, we tested the responses of dendritic cells (DC), Kupffer cells (KC, the resident macrophages of the liver) and Natural Killer T (NKT) cells in the liver, as well as in adipose tissue. To address this hypothesis, we developed two model systems to artificially alter the immune system while monitoring changes within the liver and/or adipose tissue. First, we established an in vitro co-culture model of the liver with mouse hepatocytes and KC to study interactions between the two cell types. Second, we established an adoptive transfer protocol to exogenously increase the numbers of macrophages and various types of DC in mice consuming a high fat diet. Finally, we utilized the CD1d-/- mouse line to clarify an important controversy regarding the involvement of NKT cells in the metabolic disturbances of obesity.We found that KC decrease hepatocyte palmitate oxidation and identified prostaglandin E2 (PGE2) as a potential mediator of this effect. Furthermore, the liver and adipose tissue of mice receiving weekly injections of immature bone marrow-derived DC are skewed towards a predominantly TH2, or anti-inflammatory, phenotype. Additionally, these mice accumulate less fat and are partially protected against diet-induced insulin resistance. Also, we illustrate that removal of NKT cells does not alter insulin resistance or steatosis when consuming a high fat diet (HFD).In conclusion, we have demonstrated that responses of immune cells within theliver alter lipid metabolism and can induce changes consistent with the development of steatosis. Additionally, DC play an integral role in the determination of body composition and insulin sensitivity when challenged with a HFD. And finally, NKT cells may not be involved in the development of the metabolic disturbances of obesity." @default.
• W91956051 created "2016-06-24" @default.
• W91956051 creator A5021656346 @default.
• W91956051 date "2011-11-21" @default.
• W91956051 modified "2023-09-27" @default.
• W91956051 title "IMMUNE MODULATION OF METABOLISM: THE ROLE OF MACROPHAGES, NKTCELLS AND DENDRITIC CELLS IN THE DEVELOPMENT OF THE METABOLICDISTURBANCES OF OBESITY" @default.
• W91956051 cites W131214026 @default.
• W91956051 cites W1505106993 @default.
• W91956051 cites W1534360145 @default.
• W91956051 cites W1554022361 @default.
• W91956051 cites W1558367558 @default.
• W91956051 cites W1595730385 @default.
• W91956051 cites W1602331691 @default.
• W91956051 cites W1661544713 @default.
• W91956051 cites W1764140709 @default.
• W91956051 cites W1828550268 @default.
• W91956051 cites W1901777596 @default.
• W91956051 cites W1953077261 @default.
• W91956051 cites W1964774089 @default.
• W91956051 cites W1966648877 @default.
• W91956051 cites W1966960296 @default.
• W91956051 cites W1974033843 @default.
• W91956051 cites W1974599416 @default.
• W91956051 cites W1975088204 @default.
• W91956051 cites W1975537939 @default.
• W91956051 cites W1978248654 @default.
• W91956051 cites W1978805605 @default.
• W91956051 cites W1979454503 @default.
• W91956051 cites W1987915694 @default.
• W91956051 cites W1989518765 @default.
• W91956051 cites W1991401793 @default.
• W91956051 cites W1991795789 @default.
• W91956051 cites W1992919103 @default.
• W91956051 cites W1995744610 @default.
• W91956051 cites W1999154027 @default.
• W91956051 cites W2000050828 @default.
• W91956051 cites W2000054651 @default.
• W91956051 cites W2006498696 @default.
• W91956051 cites W2008381613 @default.
• W91956051 cites W2008869160 @default.
• W91956051 cites W2011255130 @default.
• W91956051 cites W2013356100 @default.
• W91956051 cites W2014601653 @default.
• W91956051 cites W2016329695 @default.
• W91956051 cites W2018192258 @default.
• W91956051 cites W2021872118 @default.
• W91956051 cites W2022104437 @default.
• W91956051 cites W2022420894 @default.
• W91956051 cites W2022801078 @default.
• W91956051 cites W2025732533 @default.
• W91956051 cites W2026483481 @default.
• W91956051 cites W2026578316 @default.
• W91956051 cites W2028089693 @default.
• W91956051 cites W2030822765 @default.
• W91956051 cites W2031181420 @default.
• W91956051 cites W2031637294 @default.
• W91956051 cites W2036227669 @default.
• W91956051 cites W2037997647 @default.
• W91956051 cites W2038689279 @default.
• W91956051 cites W2038846370 @default.
• W91956051 cites W2041176514 @default.
• W91956051 cites W2043106623 @default.
• W91956051 cites W2043523201 @default.
• W91956051 cites W2044306159 @default.
• W91956051 cites W2046783872 @default.
• W91956051 cites W2046859247 @default.
• W91956051 cites W2046935888 @default.
• W91956051 cites W2047467264 @default.
• W91956051 cites W2049293705 @default.
• W91956051 cites W2050764448 @default.
• W91956051 cites W2051051060 @default.
• W91956051 cites W2053220365 @default.
• W91956051 cites W2059842910 @default.
• W91956051 cites W2062133020 @default.
• W91956051 cites W2062274484 @default.
• W91956051 cites W2063131576 @default.
• W91956051 cites W2063441372 @default.
• W91956051 cites W2064662152 @default.
• W91956051 cites W2069100407 @default.
• W91956051 cites W2070945317 @default.
• W91956051 cites W2073415492 @default.
• W91956051 cites W2073578515 @default.
• W91956051 cites W2077724247 @default.
• W91956051 cites W2079731322 @default.
• W91956051 cites W2083666530 @default.
• W91956051 cites W2084605753 @default.
• W91956051 cites W2086049904 @default.
• W91956051 cites W2094644629 @default.
• W91956051 cites W2095717717 @default.
• W91956051 cites W2097838137 @default.
• W91956051 cites W2099444411 @default.
• W91956051 cites W2099702416 @default.
• W91956051 cites W2101328621 @default.
• W91956051 cites W2102433321 @default.
• W91956051 cites W2103430792 @default.
• W91956051 cites W2103600875 @default.
• W91956051 cites W2104033287 @default.
• W91956051 cites W2105116511 @default.
• W91956051 cites W2107550410 @default.
• W91956051 cites W2107683043 @default.

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