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- W919602893 abstract "Objective: We sought relationships between the peripapillary retinal nerve fiber layer (P-RNFL) and each layer of the macula in acute and chronic papillitis and compared them to eyes with papilledema.Background: Optical coherence tomography (OCT) demonstrates swelling of the optic nerve head (ONH) and P-RNFL in patients with acute papilledema due to intracranial hypertension and with anterior optic neuritis (papillitis). As these conditions become chronic, atrophy of retinal ganglion cell (RGC) axons develops.Design/Methods: We analyzed spectral-domain OCT in eyes with papillitis during acute and chronic phases (13 eyes) and compared results to a large cohort of eyes with papilledema associated with intracranial hypertension (88 eyes). We performed regression analysis for each patient group, comparing P-RNFL and individual macular layer values.Results: There were highly significant positive correlations between mean P-RNFL thickness and the volumes of each of the three inner retinal layers (RNFL, GCL and IPL) in chronic eyes with normal or thinned P-RNFLs, but not in eyes with acute ONH swelling. In the latter, there were trends toward positive correlation only in the macular RNFL, which was weakly significant only in the larger papilledema group. In both papillitis and papilledema, there was no correlation between P-RNFL and the outer retinal layers. Relationships of P-RNFL and retinal layer volumes were very similar in papillitis and papilledema eyes.Conclusions: Conditions that cause swelling of RGC axons at the ONH may induce slight thickening of the macular RNFL, but not of the underlying GCL and IPL that contain RGC cell bodies and dendrites nor of the outer retinal layers. In contrast, loss of RGC axons associated with chronic papilledema or papillitis causes retrograde degeneration in the macular RNFL, GCL and IPL. Recognition of the normal, close relationship between the P-RNFL and inner retinal layers may allow early detection of RGC swelling. Disclosure: Dr. Abukhalil has nothing to disclose. Dr. Morrow has nothing to disclose." @default.
- W919602893 created "2016-06-24" @default.
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- W919602893 date "2015-04-06" @default.
- W919602893 modified "2023-09-23" @default.
- W919602893 title "OCT shows Different Relationships between Macular Layers and Peripapillary RNFL in Acute versus Chronic Papillitis and Papilledema (P1.325)" @default.
- W919602893 hasPublicationYear "2015" @default.
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