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• W919658712 abstract "Vitamin A has preventive effects on obesity. All-trans retinoic acid (ATRA), the active form of vitamin A, inhibits lipid accumulation in 3T3-L1 cells in an experimental adipogenesis model. We found that ATRA suppressed up-regulation of the amino acid transporter, Asct2, in adipogenerating 3T3-L1 cells. We observed that Asct2 was up-regulated at 1 day after adipogenesis stimuli. The Asct2 inhibitor l-γ-glutamyl-p-nitroanilide (GPNA) decreased lipid accumulation. Glutamine-free conditions also suppressed adipogenesis. Suppression of adipogenesis by ATRA may be through Asct2 reduction. These results indicate that Asct2 could be a target for obesity prevention and treatment." @default.
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• W919658712 date "2015-01-01" @default.
• W919658712 modified "2023-10-16" @default.
• W919658712 title "Inhibition of ASCT2 is essential in all‐ <i>trans</i> retinoic acid‐induced reduction of adipogenesis in 3T3‐L1 cells" @default.
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• W919658712 doi "https://doi.org/10.1016/j.fob.2015.06.012" @default.
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