FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W92044824> ?p ?o ?g. }

• W92044824 endingPage "40" @default.
• W92044824 startingPage "32" @default.
• W92044824 abstract "Background: Lung contusion (LC) is an independent risk factor for acute respiratory distress syndrome. The final common pathway in ARDS involves accumulation of fluid in the alveoli. In this study, we demonstrate the application of a potential gene therapy approach by delivering the Na+/K+-ATPase pump subunits in a murine model of LC. We hypothesized that restoring the activity of the pump will result in removal of excess alveolar fluid and additionally reduce inflammation. Methods: Under anesthesia, C57/BL6 mice were struck along the right posterior axillary line 1 cm above the costal margin with a cortical contusion impactor. Immediately afterward, 100 μg of plasmid DNA coding for the α,β of the Na+/K+-ATPase pump were instilled into the lungs (LC-electroporation-pump group). Contusion only (LC-only) and a sham saline instillation group after contusion were used as controls (LC-electroporation-sham). By using a BTX 830 electroporator, eight electrical pulses of 200 V/cm field strength were applied transthoracically. Mice were killed at 24 hours, 48 hours, and 72 hours after delivery. Bronchial alveolar lavage was recollected to measure albumin and cytokines by enzyme-linked immunosorbent assay. Pulmonary compliance was measured, and lungs were subject to histopathologic analysis. Results: After the electroporation and delivery of genes coding for the α,β subunits of the Na+/K+-ATPase pump, there was a significant mitigation of acute lung injury as evidenced by reduction in bronchial alveolar lavage levels of albumin, improved pressure volume curves, and reduced inflammation seen on histology. Conclusion: Electroporation-mediated gene transfer of the subunits of the Na+/K+-ATPase pump enhanced recovery from acute inflammatory lung injury after LC." @default.
• W92044824 created "2016-06-24" @default.
• W92044824 creator A5011094740 @default.
• W92044824 creator A5018728349 @default.
• W92044824 creator A5059865743 @default.
• W92044824 creator A5088661513 @default.
• W92044824 date "2012-01-01" @default.
• W92044824 modified "2023-09-27" @default.
• W92044824 title "Electroporation-mediated in vivo gene delivery of the Na+/K+-ATPase pump reduced lung injury in a mouse model of lung contusion" @default.
• W92044824 cites W1986543193 @default.
• W92044824 cites W1987355473 @default.
• W92044824 cites W1996401569 @default.
• W92044824 cites W2001661716 @default.
• W92044824 cites W2004638168 @default.
• W92044824 cites W2008049480 @default.
• W92044824 cites W2013768944 @default.
• W92044824 cites W2019140768 @default.
• W92044824 cites W2019611732 @default.
• W92044824 cites W2025986543 @default.
• W92044824 cites W2026551182 @default.
• W92044824 cites W2040948089 @default.
• W92044824 cites W2045703009 @default.
• W92044824 cites W2059141314 @default.
• W92044824 cites W2066429582 @default.
• W92044824 cites W2068196810 @default.
• W92044824 cites W2068572134 @default.
• W92044824 cites W2068854215 @default.
• W92044824 cites W2075982355 @default.
• W92044824 cites W2079894038 @default.
• W92044824 cites W2087694776 @default.
• W92044824 cites W2089072626 @default.
• W92044824 cites W2095446875 @default.
• W92044824 cites W2097823269 @default.
• W92044824 cites W2106044963 @default.
• W92044824 cites W2117164219 @default.
• W92044824 cites W2172201608 @default.
• W92044824 cites W2178840694 @default.
• W92044824 cites W2312848410 @default.
• W92044824 cites W4236874479 @default.
• W92044824 cites W4294658238 @default.
• W92044824 doi "https://doi.org/10.1097/ta.0b013e31823f0606" @default.
• W92044824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3275777" @default.
• W92044824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22310113" @default.
• W92044824 hasPublicationYear "2012" @default.
• W92044824 type Work @default.
• W92044824 sameAs 92044824 @default.
• W92044824 citedByCount "15" @default.
• W92044824 countsByYear W920448242013 @default.
• W92044824 countsByYear W920448242014 @default.
• W92044824 countsByYear W920448242015 @default.
• W92044824 countsByYear W920448242016 @default.
• W92044824 countsByYear W920448242018 @default.
• W92044824 countsByYear W920448242019 @default.
• W92044824 countsByYear W920448242020 @default.
• W92044824 countsByYear W920448242022 @default.
• W92044824 countsByYear W920448242023 @default.
• W92044824 crossrefType "journal-article" @default.
• W92044824 hasAuthorship W92044824A5011094740 @default.
• W92044824 hasAuthorship W92044824A5018728349 @default.
• W92044824 hasAuthorship W92044824A5059865743 @default.
• W92044824 hasAuthorship W92044824A5088661513 @default.
• W92044824 hasBestOaLocation W920448242 @default.
• W92044824 hasConcept C104317684 @default.
• W92044824 hasConcept C111599444 @default.
• W92044824 hasConcept C126322002 @default.
• W92044824 hasConcept C135983454 @default.
• W92044824 hasConcept C142724271 @default.
• W92044824 hasConcept C150903083 @default.
• W92044824 hasConcept C16685009 @default.
• W92044824 hasConcept C185592680 @default.
• W92044824 hasConcept C186852380 @default.
• W92044824 hasConcept C207001950 @default.
• W92044824 hasConcept C2776232574 @default.
• W92044824 hasConcept C2776348555 @default.
• W92044824 hasConcept C2776694085 @default.
• W92044824 hasConcept C2777714996 @default.
• W92044824 hasConcept C42219234 @default.
• W92044824 hasConcept C55493867 @default.
• W92044824 hasConcept C71924100 @default.
• W92044824 hasConcept C86803240 @default.
• W92044824 hasConceptScore W92044824C104317684 @default.
• W92044824 hasConceptScore W92044824C111599444 @default.
• W92044824 hasConceptScore W92044824C126322002 @default.
• W92044824 hasConceptScore W92044824C135983454 @default.
• W92044824 hasConceptScore W92044824C142724271 @default.
• W92044824 hasConceptScore W92044824C150903083 @default.
• W92044824 hasConceptScore W92044824C16685009 @default.
• W92044824 hasConceptScore W92044824C185592680 @default.
• W92044824 hasConceptScore W92044824C186852380 @default.
• W92044824 hasConceptScore W92044824C207001950 @default.
• W92044824 hasConceptScore W92044824C2776232574 @default.
• W92044824 hasConceptScore W92044824C2776348555 @default.
• W92044824 hasConceptScore W92044824C2776694085 @default.
• W92044824 hasConceptScore W92044824C2777714996 @default.
• W92044824 hasConceptScore W92044824C42219234 @default.
• W92044824 hasConceptScore W92044824C55493867 @default.
• W92044824 hasConceptScore W92044824C71924100 @default.
• W92044824 hasConceptScore W92044824C86803240 @default.

• next