FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W92059239> ?p ?o ?g. }

• W92059239 endingPage "1394" @default.
• W92059239 startingPage "1394a" @default.
• W92059239 abstract "Editor—Koning et al report the results of a clinical trial that showed the efficacy of topical fusidic acid as treatment of patients with impetigo.1 This agent has been recommended by the Dutch College of General Practitioners as the treatment of choice in patients with this infection. Koning et al observed that none of the pretreatment isolates of Staphylococcus aureus was resistant to fusidic acid and concluded that many years of use of topical fusidic acid has not resulted in appreciable resistance in staphylococci in the general population.These findings illustrate one of the problems surrounding antimicrobial resistance—namely, that patterns of resistance in one country cannot be extrapolated to those in another. Specifically, data for resistance rates to fusidic acid among S aureus isolates in the United Kingdom differ markedly from those in the Netherlands. In a survey of 28 centres in the United Kingdom the incidence of resistance to fusidic acid among S aureus isolates from the community (excluding strains of methicillin resistant S aureus, which, by their clonal nature, might distort the data) increased from 8.1% in 1995 to 17.3% in 2001 (figure) (R Wise, unpublished data).2 A similar study carried out in Bristol showed an approximately twofold increase in resistance rates (from 6% to 11.5%) among methicillin susceptible S aureus strains isolated between 1998 and 2001.3The figure also shows that between 1995 and 2001 the number of prescriptions of fusidic acid in the United Kingdom (expressed as total units dispensed and accounted for almost entirely by the topical formulation) nearly doubled (data supplied by Leo Pharmaceuticals). We cannot explain why the Dutch experience does not mirror our own, although Koning et al have not specified the technique they used to determine the susceptibilities of their isolates, nor have they provided information about the susceptibilities to fusidic acid of any isolates after treatment. A further confounding factor could be the small number of isolates tested (67 strains); evaluating a larger, and therefore more representative, sample might yield a different pattern of resistance.We do not dispute the efficacy of topical fusidic acid as treatment of patients with impetigo and other superficial skin infections. But fusidic acid is a very valuable drug that is also administered systemically in combination with another antistaphylococcal antibiotic, usually flucloxacillin, as treatment of patients with severe staphylococcal infections. Rates of resistance to this agent among S aureus isolates are increasing in the United Kingdom, directly in line with usage, and we are concerned that further increases in the prescribing of topical fusidic acid will result in even higher levels of resistance. The price of continuing to administer the drug in this way will, in the long term, be the loss of the therapeutic efficacies of both the topical and systemic formulations, and we urge restraint, particularly among general practitioners and dermatologists." @default.
• W92059239 created "2016-06-24" @default.
• W92059239 creator A5035047751 @default.
• W92059239 creator A5053616372 @default.
• W92059239 date "2002-06-08" @default.
• W92059239 modified "2023-09-27" @default.
• W92059239 title "Fusidic acid cream for impetigo" @default.
• W92059239 cites W1983742247 @default.
• W92059239 cites W1986984633 @default.
• W92059239 cites W2003421192 @default.
• W92059239 cites W2010453722 @default.
• W92059239 cites W2013503894 @default.
• W92059239 cites W2060297492 @default.
• W92059239 cites W2091378997 @default.
• W92059239 cites W2133982391 @default.
• W92059239 cites W2134959152 @default.
• W92059239 cites W2144979349 @default.
• W92059239 cites W2167386948 @default.
• W92059239 doi "https://doi.org/10.1136/bmj.324.7350.1394/a" @default.
• W92059239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1123338" @default.
• W92059239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12052817" @default.
• W92059239 hasPublicationYear "2002" @default.
• W92059239 type Work @default.
• W92059239 sameAs 92059239 @default.
• W92059239 citedByCount "30" @default.
• W92059239 countsByYear W920592392012 @default.
• W92059239 countsByYear W920592392014 @default.
• W92059239 countsByYear W920592392015 @default.
• W92059239 countsByYear W920592392016 @default.
• W92059239 countsByYear W920592392019 @default.
• W92059239 countsByYear W920592392020 @default.
• W92059239 countsByYear W920592392021 @default.
• W92059239 crossrefType "journal-article" @default.
• W92059239 hasAuthorship W92059239A5035047751 @default.
• W92059239 hasAuthorship W92059239A5053616372 @default.
• W92059239 hasBestOaLocation W920592392 @default.
• W92059239 hasConcept C16005928 @default.
• W92059239 hasConcept C2778811088 @default.
• W92059239 hasConcept C2779489039 @default.
• W92059239 hasConcept C2780483375 @default.
• W92059239 hasConcept C523546767 @default.
• W92059239 hasConcept C54355233 @default.
• W92059239 hasConcept C71924100 @default.
• W92059239 hasConcept C86803240 @default.
• W92059239 hasConceptScore W92059239C16005928 @default.
• W92059239 hasConceptScore W92059239C2778811088 @default.
• W92059239 hasConceptScore W92059239C2779489039 @default.
• W92059239 hasConceptScore W92059239C2780483375 @default.
• W92059239 hasConceptScore W92059239C523546767 @default.
• W92059239 hasConceptScore W92059239C54355233 @default.
• W92059239 hasConceptScore W92059239C71924100 @default.
• W92059239 hasConceptScore W92059239C86803240 @default.
• W92059239 hasIssue "7350" @default.
• W92059239 hasLocation W920592391 @default.
• W92059239 hasLocation W920592392 @default.
• W92059239 hasLocation W920592393 @default.
• W92059239 hasLocation W920592394 @default.
• W92059239 hasOpenAccess W92059239 @default.
• W92059239 hasPrimaryLocation W920592391 @default.
• W92059239 hasRelatedWork W2100785214 @default.
• W92059239 hasRelatedWork W2108164360 @default.
• W92059239 hasRelatedWork W2141901771 @default.
• W92059239 hasRelatedWork W2344705665 @default.
• W92059239 hasRelatedWork W2386418580 @default.
• W92059239 hasRelatedWork W2411607637 @default.
• W92059239 hasRelatedWork W2414524709 @default.
• W92059239 hasRelatedWork W2467192802 @default.
• W92059239 hasRelatedWork W2533540854 @default.
• W92059239 hasRelatedWork W2915764774 @default.
• W92059239 hasVolume "324" @default.
• W92059239 isParatext "false" @default.
• W92059239 isRetracted "false" @default.
• W92059239 magId "92059239" @default.
• W92059239 workType "article" @default.