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- W921568307 abstract "目的探讨不同配方肠外营养对肝硬化大鼠肝部分切除术后生长激素/胰岛素样生长因子-1轴的影响.方法正常大鼠作为对照组,肝硬化大鼠随机分为肝硬化术前组,肝硬化肝部分切除术后1 d组,术后行Novamin肠外营养5 d组,术后行Hepa肠外营养5 d组,各组n=6.测大鼠肝功能、血糖及血清GH、IGF-1、IGFBP-3水平,用RT-PCR法检测肝ALBmRNA、IGF-1 mRNA、IGFBP-3mRNA的表达,肝组织行Ki67免疫组化染色.结果 Hepa组肠外营养5 d后血清ALT、ALP、GH分别为(103±23)IU/L、(571±92)IU/L、(1.55±0.12)ng/ml,均比Novamin组明显降低,而血清IGF-1、IGFPB-3分别为(966.4±54.7)ng/ml、(6.9±0.2)ng/ml,均明显升高,肝ALBmRNA、IGF-1mRNA、IGFBP-3mRNA表达水平分别为(1.24±0.06)、(0.85±0.00)、(0.69±0.02),也明显升高,但肝Ki67指数(4.8%±0.3% vs 4.4%±0.4%)却无显著性差异.血清IGF-1、IGFPB-3与血清AST、ALT、ALP水平呈负相关,与血清ALB呈正相关.结论肝硬化大鼠不同配方肠外营养均可反映在生长激素/胰岛素样生长因子-1轴的变化,检测血清IGF-1,IGFBP-3水平有助于营养素的选择." @default.
- W921568307 created "2016-06-24" @default.
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- W921568307 date "2005-01-01" @default.
- W921568307 modified "2023-09-24" @default.
- W921568307 title "不同配方肠外营养对肝硬化大鼠生长激素／胰岛素样生长因子-1轴的影响" @default.
- W921568307 hasPublicationYear "2005" @default.
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