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- W92164524 abstract "Abstract Natural killer (NK) lymphocytes play roles in the innate immune defense against tumors and viruses but also participate in graft-versus-host disease and organ transplant rejection. Selective immunomodulation of NK cell subsets would therefore prove beneficial. We have found that human NK cells express two types of potassium channels: Kv1.3 and KCa3.1. Interestingly, NK cells adherent to plastic in the presence of cytokines up-regulate KCa3.1 channels while non-adherent NK cells up-regulate Kv1.3 channels. In going with these results, we found that selective blockers of Kv1.3 channels preferentially inhibited natural cytotoxicity, antibody-mediated cytotoxicity and Fas-mediated cytotoxicity by non-adherent NK cells while selective blockers of KCa3.1 channels preferentially targeted adherent NK cells. We observed the same dichotomy when studying the effects of potassium channel blockers on the ability of adherent and non-adherent NK cells to proliferate and produce cytokines. We have successfully used selective Kv1.3 channel blockers to inhibit autoreactive T lymphocytes for the treatment of autoimmune diseases without inducing generalized immunosuppression. Targeting NK cell potassium channels may prove beneficial for the selective immunomodulation of NK cell subsets. Funded by the American Heart Association and Baylor College of Medicine." @default.
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- W92164524 date "2009-04-01" @default.
- W92164524 modified "2023-09-26" @default.
- W92164524 title "Targeting natural killer cell potassium channels for selective immunomodulation (134.14)" @default.
- W92164524 doi "https://doi.org/10.4049/jimmunol.182.supp.134.14" @default.
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