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- W9224192 abstract "ABSTRACT Objective: To determine if a clinical or functional parameter in ALS patients in a stable condition could predict spontaneous cough ineffectiveness during a respiratory tract infection (RTI). Materials and method: Forty consecutive ALS patients, one-year prospective follow-up. Measurements: FEV 1 , FVC, FEV 1 /FVC, peak cough flow (PCF), peak velocity time (PVT) maximum inspiratory (PImax) and expiratory pressure (PEmax). Bulbar dysfunction evaluation: Norris scale bulbar sub-score (NBS). Results: Twenty-six patients (65%) had spontaneous cough ineffectiveness during an RTI . The best variables to predict non-assisted cough during an RTI were NBS (p<0.01) with a cut-off point of 29 (sensitivity 0.89, specificity 0.90, positive predicted value 0.88, negative predictive value 0.87), PCF (p<0.001) with a cut-off point of 4.25 L/s (sensitivity 0.74, specificity 0.85, positive predictive value 0.71, negative predictive value 0.85) and PCF/PVT (p<0.001) with a cut-off point of 28.88 L/s" @default.
- W9224192 created "2016-06-24" @default.
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- W9224192 date "2007-01-01" @default.
- W9224192 modified "2023-10-04" @default.
- W9224192 title "PREDICTORS OF INEFFECTIVE COUGH DURING A CHEST INFECTION IN STABLE ALS PATIENTS" @default.
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