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- W922722444 abstract "Objective To investigate the role of mifepristone in regulating cytokines of maternofetal interface and serum of human early gestation Methods Thirty-five women with early pregnancy received mifepristone 50 mg orally on study d 1 and d 2, respectively, followed by undergoing artificial abortion to get decidua and villi on study d 3. Twenty-five women with early pregnancy without mifepristone administration as control also underwent artificial abortion to get decidua and villi. The expressions of TGF-β1 and TGF-β1 receptor mRNA in the early decidua and villi were assessed by using RT-PCR . The concentrations of serum TNFα were measured by radioimmunoassay.Results The decidual expressions of TGF- β1 mRNA and TGF-β1 receptor mRNA in the treated group were significantly lower than those of the control (P＜0.05), while the villus expressions of TGF-β1 and TGF-β1 receptor mRNA in the treated group were not significantly different from those of the control (P＞0. 05). The serum TNF-β1 levels elevated significantly after mifepristone treatment.Conclusion The antigestational effect of mifepristone might act through suppressing the transcription of TGF-β1 and TGF-β1 receptor in the decidua and increasing the serum TNF-α level, which interfered in the materno-fetal interface Th2 bias." @default.
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- W922722444 date "2004-01-01" @default.
- W922722444 modified "2023-09-23" @default.
- W922722444 title "Effect of Mifepristone on Transforming Growth Factor-β and its Receptor Transcription in Decidua, Villi and Serum Tumor Necrosis Factor -α Level in Early Human Gestation" @default.
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