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- W922803089 startingPage "37" @default.
- W922803089 abstract "Tick-borne pathogens, especially the ehrlichias, anaplasmas, and spirochetes, are recognized as causing a growing spectrum of diseases in domestic and feral animals and humans. One of the underlying principles governing the life cycle of tick-borne pathogens is their ability to survive and thrive in two extremely different environments—one presented by the homeostatic environment of the mammal, and the other presented by the vector tick, under conditions that change dramatically with activity and feeding status. The microbes must be able to sense pathophysiological changes in their hosts, distinguish the multitude of signals received, and react appropriately. Differential expression of specific antigens (DESA) mediates transition to the new host. This chapter highlights what is known about the response of these microbes to host cues and how they manage existence in and passage between the divergent environments of mammalian host and vector tick. It focuses on the human pathogenic rickettsiae and spirochetes as they prepare to leave the ticks and invade the mammalian host. The chapter also covers the basic features of the tick as a microbial environment and how the tick environment differs from that of the vertebrate host and how ticks recognize and respond to microbial invaders." @default.
- W922803089 created "2016-06-24" @default.
- W922803089 creator A5016126113 @default.
- W922803089 creator A5036360934 @default.
- W922803089 creator A5089410308 @default.
- W922803089 date "2014-04-08" @default.
- W922803089 modified "2023-10-17" @default.
- W922803089 title "The Tick: a Different Kind of Host for Human Pathogens" @default.
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