FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W923505587> ?p ?o ?g. }

• W923505587 endingPage "46" @default.
• W923505587 startingPage "31" @default.
• W923505587 abstract "The inhibitory IgG Fc receptor (FcγRIIB) deficiency and 129 strain-derived signaling lymphocyte activation molecules (129-SLAMs) are proposed to contribute to the lupus phenotype in FcγRIIB-deficient mice generated using 129 ES cells and backcrossed to C57BL/6 mice (B6.129.RIIBKO). In this study, we examine the individual contributions and the cellular mechanisms by which FcγRIIB deficiency and 129-derived SLAM family genes promote dysregulated spontaneous germinal center (Spt-GC) B cell and follicular helper T cell (Tfh) responses in B6.129.RIIBKO mice. We find that B6 mice congenic for the 129-derived SLAM locus (B6.129-SLAM) and B6 mice deficient in FcγRIIB (B6.RIIBKO) have increased Spt-GC B cell responses compared to B6 controls but significantly lower than B6.129.RIIBKO mice. These data indicate that both FcγRIIB deficiency and 129-SLAMs contribute to elevated Spt-GC B cell responses in B6.129.RIIBKO mice. However, only 129-SLAMs contribute significantly to augmented Tfh responses in B6.129.RIIBKO mice, and do so by a combination of T cell-dependent effects and enhanced B cell and DC-dependent antigen presentation to T cells. Elevated Spt-GC B cell responses in mice with FcγRIIB deficiency and polymorphic 129-SLAMs were associated with elevated metabolic activity, improved GC B cell survival and increased differentiation of naïve B cells into GC B cell phenotype. Our data suggest that the interplay between 129-SLAM expression on B cells, T cells and DCs is central to the alteration of the GC tolerance checkpoint, and that deficiency of FcγRIIB on B cells is necessary to augment Spt-GC responses, pathogenic autoantibodies, and lupus disease." @default.
• W923505587 created "2016-06-24" @default.
• W923505587 creator A5004491636 @default.
• W923505587 creator A5014029380 @default.
• W923505587 creator A5026909486 @default.
• W923505587 creator A5038147120 @default.
• W923505587 creator A5040205085 @default.
• W923505587 creator A5041207784 @default.
• W923505587 creator A5071573524 @default.
• W923505587 creator A5082587122 @default.
• W923505587 creator A5084538418 @default.
• W923505587 creator A5085221178 @default.
• W923505587 date "2015-09-01" @default.
• W923505587 modified "2023-09-27" @default.
• W923505587 title "Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity" @default.
• W923505587 cites W1481215660 @default.
• W923505587 cites W1494703672 @default.
• W923505587 cites W1544832651 @default.
• W923505587 cites W1568498698 @default.
• W923505587 cites W1576474939 @default.
• W923505587 cites W1589497644 @default.
• W923505587 cites W1593087694 @default.
• W923505587 cites W1648730905 @default.
• W923505587 cites W1726858145 @default.
• W923505587 cites W1806152992 @default.
• W923505587 cites W1918778447 @default.
• W923505587 cites W1926727282 @default.
• W923505587 cites W1952811618 @default.
• W923505587 cites W1982861708 @default.
• W923505587 cites W1983940041 @default.
• W923505587 cites W1995703209 @default.
• W923505587 cites W1995928270 @default.
• W923505587 cites W1999049076 @default.
• W923505587 cites W2001775594 @default.
• W923505587 cites W2002116270 @default.
• W923505587 cites W2005894429 @default.
• W923505587 cites W2019383774 @default.
• W923505587 cites W2021632539 @default.
• W923505587 cites W2033134260 @default.
• W923505587 cites W2033527049 @default.
• W923505587 cites W2034815827 @default.
• W923505587 cites W2040391992 @default.
• W923505587 cites W2042797177 @default.
• W923505587 cites W2043263210 @default.
• W923505587 cites W2044567576 @default.
• W923505587 cites W2046334248 @default.
• W923505587 cites W2046752806 @default.
• W923505587 cites W2047345480 @default.
• W923505587 cites W2056462157 @default.
• W923505587 cites W2063803021 @default.
• W923505587 cites W2069047496 @default.
• W923505587 cites W2072980588 @default.
• W923505587 cites W2074290635 @default.
• W923505587 cites W2075901113 @default.
• W923505587 cites W2081708412 @default.
• W923505587 cites W2082922286 @default.
• W923505587 cites W2086542713 @default.
• W923505587 cites W2088002019 @default.
• W923505587 cites W2100612316 @default.
• W923505587 cites W2106663757 @default.
• W923505587 cites W2107349643 @default.
• W923505587 cites W2108072531 @default.
• W923505587 cites W2113932056 @default.
• W923505587 cites W2122510983 @default.
• W923505587 cites W2122877291 @default.
• W923505587 cites W2123130879 @default.
• W923505587 cites W2131536368 @default.
• W923505587 cites W2135507348 @default.
• W923505587 cites W2142307845 @default.
• W923505587 cites W2144309235 @default.
• W923505587 cites W2147449671 @default.
• W923505587 cites W2149884235 @default.
• W923505587 cites W2161285087 @default.
• W923505587 cites W2169317161 @default.
• W923505587 cites W54413410 @default.
• W923505587 cites W2022305989 @default.
• W923505587 doi "https://doi.org/10.1016/j.jaut.2015.06.011" @default.
• W923505587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4564365" @default.
• W923505587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26162758" @default.
• W923505587 hasPublicationYear "2015" @default.
• W923505587 type Work @default.
• W923505587 sameAs 923505587 @default.
• W923505587 citedByCount "20" @default.
• W923505587 countsByYear W9235055872016 @default.
• W923505587 countsByYear W9235055872017 @default.
• W923505587 countsByYear W9235055872018 @default.
• W923505587 countsByYear W9235055872019 @default.
• W923505587 countsByYear W9235055872020 @default.
• W923505587 countsByYear W9235055872021 @default.
• W923505587 countsByYear W9235055872023 @default.
• W923505587 crossrefType "journal-article" @default.
• W923505587 hasAuthorship W923505587A5004491636 @default.
• W923505587 hasAuthorship W923505587A5014029380 @default.
• W923505587 hasAuthorship W923505587A5026909486 @default.
• W923505587 hasAuthorship W923505587A5038147120 @default.
• W923505587 hasAuthorship W923505587A5040205085 @default.
• W923505587 hasAuthorship W923505587A5041207784 @default.
• W923505587 hasAuthorship W923505587A5071573524 @default.

• next