FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W92409275> ?p ?o ?g. }

• W92409275 endingPage "262" @default.
• W92409275 startingPage "253" @default.
• W92409275 abstract "Background Silver nanoparticles have been shown to exhibit promising cytoprotective activities towards HIV-infected T-cells; however, the effects of these nanoparticles towards other kinds of viruses remain largely unexplored. The aim of the present study was to investigate the effects of silver nanoparticles on hepatitis B virus (HBV). Methods Monodisperse silver nanoparticles with mean particle diameters of ∼10 nm (Ag10Ns) and ∼50 nm (Ag50Ns) were prepared from AgNO 3 in HEPES buffer. The in vitro anti-HBV activities of these particles were determined using the HepAD38 cell line as infection model. Results Ag10Ns and Ag50Ns were able to reduce the extracellular HBV DNA formation of HepAD38 cells by >50% compared with the vehicle control (that is, HepAD38 cells in the absence of silver nanoparticles). Silver nanoparticles had little effect on the amount of HBV covalently closed circular DNA (cccDNA), but could inhibit the formation of intracellular HBV RNA. Gel mobility shift assays indicated that Ag10Ns bound HBV double-stranded DNA at a DNA:silver molar ratio of 1:50; an absorption titration assay showed that the nanoparticles have good binding affinity for HBV DNA with a binding constant ( K b ) of (8.8 ±1.0)x10 5 dm 3 mol -1 . As both the viral and Ag10Ns systems are in the nanometer size range, we found that Ag10Ns could directly interact with the HBV viral particles as revealed by transmission electronic microscopy. Conclusions Silver nanoparticles could inhibit the in vitro production of HBV RNA and extracellular virions. We hypothesize that the direct interaction between these nanoparticles and HBV double-stranded DNA or viral particles is responsible for their antiviral mechanism." @default.
• W92409275 created "2016-06-24" @default.
• W92409275 creator A5020079777 @default.
• W92409275 creator A5040977229 @default.
• W92409275 creator A5042037558 @default.
• W92409275 creator A5063514061 @default.
• W92409275 creator A5063999239 @default.
• W92409275 creator A5069748654 @default.
• W92409275 creator A5077929175 @default.
• W92409275 creator A5089804910 @default.
• W92409275 date "2008-02-01" @default.
• W92409275 modified "2023-10-18" @default.
• W92409275 title "Silver Nanoparticles Inhibit Hepatitis B virus Replication" @default.
• W92409275 cites W1795551994 @default.
• W92409275 cites W1976018739 @default.
• W92409275 cites W1984898374 @default.
• W92409275 cites W1989483691 @default.
• W92409275 cites W1990164469 @default.
• W92409275 cites W1992475294 @default.
• W92409275 cites W2007902841 @default.
• W92409275 cites W2008380896 @default.
• W92409275 cites W2008517556 @default.
• W92409275 cites W2021910827 @default.
• W92409275 cites W2025722002 @default.
• W92409275 cites W2044665743 @default.
• W92409275 cites W2044851985 @default.
• W92409275 cites W2044951291 @default.
• W92409275 cites W2060883152 @default.
• W92409275 cites W2066079726 @default.
• W92409275 cites W2077500636 @default.
• W92409275 cites W2088165891 @default.
• W92409275 cites W2095492394 @default.
• W92409275 cites W2098756966 @default.
• W92409275 cites W2104154679 @default.
• W92409275 cites W2107277218 @default.
• W92409275 cites W2114918609 @default.
• W92409275 cites W2129923672 @default.
• W92409275 cites W2143233396 @default.
• W92409275 cites W2148470013 @default.
• W92409275 cites W2156043887 @default.
• W92409275 cites W2156552801 @default.
• W92409275 cites W2341203768 @default.
• W92409275 cites W2952246018 @default.
• W92409275 doi "https://doi.org/10.1177/135965350801300210" @default.
• W92409275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18505176" @default.
• W92409275 hasPublicationYear "2008" @default.
• W92409275 type Work @default.
• W92409275 sameAs 92409275 @default.
• W92409275 citedByCount "467" @default.
• W92409275 countsByYear W924092752012 @default.
• W92409275 countsByYear W924092752013 @default.
• W92409275 countsByYear W924092752014 @default.
• W92409275 countsByYear W924092752015 @default.
• W92409275 countsByYear W924092752016 @default.
• W92409275 countsByYear W924092752017 @default.
• W92409275 countsByYear W924092752018 @default.
• W92409275 countsByYear W924092752019 @default.
• W92409275 countsByYear W924092752020 @default.
• W92409275 countsByYear W924092752021 @default.
• W92409275 countsByYear W924092752022 @default.
• W92409275 countsByYear W924092752023 @default.
• W92409275 crossrefType "journal-article" @default.
• W92409275 hasAuthorship W92409275A5020079777 @default.
• W92409275 hasAuthorship W92409275A5040977229 @default.
• W92409275 hasAuthorship W92409275A5042037558 @default.
• W92409275 hasAuthorship W92409275A5063514061 @default.
• W92409275 hasAuthorship W92409275A5063999239 @default.
• W92409275 hasAuthorship W92409275A5069748654 @default.
• W92409275 hasAuthorship W92409275A5077929175 @default.
• W92409275 hasAuthorship W92409275A5089804910 @default.
• W92409275 hasBestOaLocation W924092751 @default.
• W92409275 hasConcept C12554922 @default.
• W92409275 hasConcept C140704245 @default.
• W92409275 hasConcept C153911025 @default.
• W92409275 hasConcept C155672457 @default.
• W92409275 hasConcept C159047783 @default.
• W92409275 hasConcept C171250308 @default.
• W92409275 hasConcept C185592680 @default.
• W92409275 hasConcept C189490182 @default.
• W92409275 hasConcept C192562407 @default.
• W92409275 hasConcept C202751555 @default.
• W92409275 hasConcept C2522874641 @default.
• W92409275 hasConcept C2777382497 @default.
• W92409275 hasConcept C2777410769 @default.
• W92409275 hasConcept C2780593183 @default.
• W92409275 hasConcept C31499863 @default.
• W92409275 hasConcept C552990157 @default.
• W92409275 hasConcept C55493867 @default.
• W92409275 hasConcept C86803240 @default.
• W92409275 hasConceptScore W92409275C12554922 @default.
• W92409275 hasConceptScore W92409275C140704245 @default.
• W92409275 hasConceptScore W92409275C153911025 @default.
• W92409275 hasConceptScore W92409275C155672457 @default.
• W92409275 hasConceptScore W92409275C159047783 @default.
• W92409275 hasConceptScore W92409275C171250308 @default.
• W92409275 hasConceptScore W92409275C185592680 @default.
• W92409275 hasConceptScore W92409275C189490182 @default.
• W92409275 hasConceptScore W92409275C192562407 @default.

• next