Matches in SemOpenAlex for { <https://semopenalex.org/work/W924320022> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W924320022 endingPage "115.6" @default.
- W924320022 startingPage "115.6" @default.
- W924320022 abstract "Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease involving dysregulation of both innate and adaptive immune compartments. The hallmark of SLE is loss of B cell tolerance and production of auto-antibodies, which results in tissue damage and inflammation. Factors driving loss of B cell tolerance are incompletely characterized, but include failure of central tolerance mechanisms, inadequate clearance of cell debris, and alterations in the cytokine milieu, including elevated interferon alpha (IFNα). Our lab and others have shown that SLE neutrophils are a significant source of IFNα as well as self-antigen in the form of apoptotic debris and neutrophil extracellular traps (NETs). However, it is unknown whether neutrophils contribute to B cell activation and tolerance loss in lupus. To address this, we examined both splenic and bone marrow (BM) tissues from lupus prone mice to determine whether neutrophils secrete cytokines that alter the inflammatory milieu. Our data shows that neutrophil numbers and apoptosis are increased in lupus BM. BM neutrophils from lupus prone mice have elevated production of the B cell survival cytokines BAFF and APRIL, as well as IFNα. There was an enrichment of IFNα-producing neutrophils in the spleen in close proximity to both B and T cells. These data suggests that neutrophils likely participate in the creation of an inflammatory microenvironment that sustains auto-reactive B cells and exacerbates SLE pathogenesis in the spleen and the BM." @default.
- W924320022 created "2016-06-24" @default.
- W924320022 creator A5028347315 @default.
- W924320022 creator A5031145721 @default.
- W924320022 creator A5035076142 @default.
- W924320022 date "2015-05-01" @default.
- W924320022 modified "2023-09-25" @default.
- W924320022 title "The role of neutrophils in B cell dysregulation in systemic lupus erythematosus (BA7P.146)" @default.
- W924320022 doi "https://doi.org/10.4049/jimmunol.194.supp.115.6" @default.
- W924320022 hasPublicationYear "2015" @default.
- W924320022 type Work @default.
- W924320022 sameAs 924320022 @default.
- W924320022 citedByCount "0" @default.
- W924320022 crossrefType "journal-article" @default.
- W924320022 hasAuthorship W924320022A5028347315 @default.
- W924320022 hasAuthorship W924320022A5031145721 @default.
- W924320022 hasAuthorship W924320022A5035076142 @default.
- W924320022 hasConcept C126322002 @default.
- W924320022 hasConcept C134897094 @default.
- W924320022 hasConcept C136449434 @default.
- W924320022 hasConcept C159654299 @default.
- W924320022 hasConcept C170286685 @default.
- W924320022 hasConcept C203014093 @default.
- W924320022 hasConcept C2776912625 @default.
- W924320022 hasConcept C2776914184 @default.
- W924320022 hasConcept C2778453870 @default.
- W924320022 hasConcept C2778690821 @default.
- W924320022 hasConcept C2779134260 @default.
- W924320022 hasConcept C2780007613 @default.
- W924320022 hasConcept C2780931953 @default.
- W924320022 hasConcept C71924100 @default.
- W924320022 hasConcept C86803240 @default.
- W924320022 hasConcept C8891405 @default.
- W924320022 hasConceptScore W924320022C126322002 @default.
- W924320022 hasConceptScore W924320022C134897094 @default.
- W924320022 hasConceptScore W924320022C136449434 @default.
- W924320022 hasConceptScore W924320022C159654299 @default.
- W924320022 hasConceptScore W924320022C170286685 @default.
- W924320022 hasConceptScore W924320022C203014093 @default.
- W924320022 hasConceptScore W924320022C2776912625 @default.
- W924320022 hasConceptScore W924320022C2776914184 @default.
- W924320022 hasConceptScore W924320022C2778453870 @default.
- W924320022 hasConceptScore W924320022C2778690821 @default.
- W924320022 hasConceptScore W924320022C2779134260 @default.
- W924320022 hasConceptScore W924320022C2780007613 @default.
- W924320022 hasConceptScore W924320022C2780931953 @default.
- W924320022 hasConceptScore W924320022C71924100 @default.
- W924320022 hasConceptScore W924320022C86803240 @default.
- W924320022 hasConceptScore W924320022C8891405 @default.
- W924320022 hasIssue "1_Supplement" @default.
- W924320022 hasLocation W9243200221 @default.
- W924320022 hasOpenAccess W924320022 @default.
- W924320022 hasPrimaryLocation W9243200221 @default.
- W924320022 hasRelatedWork W1557621914 @default.
- W924320022 hasRelatedWork W1560067239 @default.
- W924320022 hasRelatedWork W2060364585 @default.
- W924320022 hasRelatedWork W2075162669 @default.
- W924320022 hasRelatedWork W2085125523 @default.
- W924320022 hasRelatedWork W2085305192 @default.
- W924320022 hasRelatedWork W2336438115 @default.
- W924320022 hasRelatedWork W2520179233 @default.
- W924320022 hasRelatedWork W3171317471 @default.
- W924320022 hasRelatedWork W4229034713 @default.
- W924320022 hasVolume "194" @default.
- W924320022 isParatext "false" @default.
- W924320022 isRetracted "false" @default.
- W924320022 magId "924320022" @default.
- W924320022 workType "article" @default.