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• W924562866 abstract "The influence of the phosphoinositide network on auxin-signaling in Arabidopsis thaliana The phytohormone auxin (IAA) is a key regulator of growth and organ formation as well as a signal for tropical responses in plants, including the model plant Arabidopsis thaliana. An IAA-gradient is established towards the basal sides of plant tissues that serves as a developmental cue or guides the direction of gravitropic bending responses. The polar distribution of IAA is mediated by auxin transport systems, especially PIN auxin efflux carriers, which localize intracellularly in a strictly polar pattern at one side of the plasma membrane of plant cells. It was a working hypothesis of this thesis that phosphoinositides (PIs), regulatory membrane phospholipids, contribute to the polar distribution of PIN-proteins and, thus, partake in auxin signaling. In previous experiments it has been established that PIs are required for plant gravitropic bending, but so far the mechanisms by which PIs or PI-derived signals interact with auxin signaling are not clear. The PI, phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) has an important function for vesicle trafficking and in recruiting proteins which are crucial for cytosis processes at the plasma membrane. A. thaliana pip5k1 pip5k2 double mutants showed reduced gravitropic bending and disturbed PIN localization, accompanied by reduced auxin transport. These results show that PtdInsP(4,5)P2 has an important role for the polar distribution of PINs and auxin. In a second part of this thesis, it was hypothesized that not only the intact lipid, PtdInsP(4,5)P2 is important for auxin signaling in plants but also PtdInsP(4,5)P2-derived inositolpolyphosphates (IPPs). In previous studies the IPP inositolhexakisphosphate (InsP6) was found as a cofactor in the structure of the auxin receptor TIR1. To address whether InsP6 had functional relevance for auxin perception, auxin-dependent processes were studied in Arabidopsis wild type and in ipk1-1 mutants and transgenic InsP 5-Ptase plants with reduced levels of InsP6. As an example for auxin-dependent tropical growth the gravitropic response of hypocotyls and roots was monitored and both ipk1-1 mutants and InsP 5-Ptase plants exhibited substantially reduced gravitropic curvature for both organs. TIR1 is a part of the SCFTIR1-complex. Binding of auxin to TIR1 mediates proteasomal degradation of AUX/IAA transcriptional repressors, enabling auxin-induced gene expression. Because changes in auxin-induced gene expression represent a read-out for TIR1 function, the induction of gravity-induced genes was monitored in root tips using transcript arrays. The array data indicate that transcript levels of auxin-dependent genes induced by gravistimulation in wild type controls were mostly not changed or differently regulated in the ipk1-1 mutants and InsP 5-Ptase plants. The findings present evidence that InsP6 is a cofactor required for full TIR1 functionality in Arabidopsis. Overall, the data presented in this thesis establish PIs and PI-derived IPPs as integral aspects of auxin signaling in A. thaliana that control the distribution of auxin as well as its perception." @default.
• W924562866 created "2016-06-24" @default.
• W924562866 creator A5009992064 @default.
• W924562866 date "2022-02-20" @default.
• W924562866 modified "2023-10-18" @default.
• W924562866 title "Die Rolle von Phosphoinositiden bei der Auxinsignalleitung von Arabidopsis thaliana" @default.
• W924562866 cites W1501088201 @default.
• W924562866 cites W1508614407 @default.
• W924562866 cites W1538490065 @default.
• W924562866 cites W1550114110 @default.
• W924562866 cites W1679562638 @default.
• W924562866 cites W1832030339 @default.
• W924562866 cites W1900359431 @default.
• W924562866 cites W1908941310 @default.
• W924562866 cites W1945859960 @default.
• W924562866 cites W1963558736 @default.
• W924562866 cites W1964366847 @default.
• W924562866 cites W1965788922 @default.
• W924562866 cites W1966522270 @default.
• W924562866 cites W1968551382 @default.
• W924562866 cites W1969960924 @default.
• W924562866 cites W1971509859 @default.
• W924562866 cites W1973138436 @default.
• W924562866 cites W1974179742 @default.
• W924562866 cites W1974699957 @default.
• W924562866 cites W1975953583 @default.
• W924562866 cites W1976563774 @default.
• W924562866 cites W1978143022 @default.
• W924562866 cites W1984769860 @default.
• W924562866 cites W1987198662 @default.
• W924562866 cites W1988157819 @default.
• W924562866 cites W1989784515 @default.
• W924562866 cites W1993924390 @default.
• W924562866 cites W1994303360 @default.
• W924562866 cites W1997349759 @default.
• W924562866 cites W1997463661 @default.
• W924562866 cites W1999127875 @default.
• W924562866 cites W2003253839 @default.
• W924562866 cites W2003757790 @default.
• W924562866 cites W2005313604 @default.
• W924562866 cites W2011020719 @default.
• W924562866 cites W2013342444 @default.
• W924562866 cites W2014953951 @default.
• W924562866 cites W2015732958 @default.
• W924562866 cites W2015747961 @default.
• W924562866 cites W2015764890 @default.
• W924562866 cites W2016509044 @default.
• W924562866 cites W2016805044 @default.
• W924562866 cites W2021738855 @default.
• W924562866 cites W2022530238 @default.
• W924562866 cites W2022908372 @default.
• W924562866 cites W2024692287 @default.
• W924562866 cites W2030716707 @default.
• W924562866 cites W2031213514 @default.
• W924562866 cites W2033139481 @default.
• W924562866 cites W2034146282 @default.
• W924562866 cites W2038749716 @default.
• W924562866 cites W2040290996 @default.
• W924562866 cites W2045405284 @default.
• W924562866 cites W2045782185 @default.
• W924562866 cites W2051548317 @default.
• W924562866 cites W2051557597 @default.
• W924562866 cites W2051871794 @default.
• W924562866 cites W2052119100 @default.
• W924562866 cites W2052969226 @default.
• W924562866 cites W2053427298 @default.
• W924562866 cites W2055323344 @default.
• W924562866 cites W2060162734 @default.
• W924562866 cites W2061381239 @default.
• W924562866 cites W2061792959 @default.
• W924562866 cites W2062397693 @default.
• W924562866 cites W2064059288 @default.
• W924562866 cites W2064770128 @default.
• W924562866 cites W2065596167 @default.
• W924562866 cites W2065652973 @default.
• W924562866 cites W2071786252 @default.
• W924562866 cites W2071833315 @default.
• W924562866 cites W2073321195 @default.
• W924562866 cites W2075406883 @default.
• W924562866 cites W2076208046 @default.
• W924562866 cites W2076381114 @default.
• W924562866 cites W2080907491 @default.
• W924562866 cites W2081996535 @default.
• W924562866 cites W2084312697 @default.
• W924562866 cites W2084533661 @default.
• W924562866 cites W2087299393 @default.
• W924562866 cites W2087534413 @default.
• W924562866 cites W2088093379 @default.
• W924562866 cites W2090686710 @default.
• W924562866 cites W2091142578 @default.
• W924562866 cites W2091407052 @default.
• W924562866 cites W2091748984 @default.
• W924562866 cites W2091868541 @default.
• W924562866 cites W2093160716 @default.
• W924562866 cites W2093414812 @default.
• W924562866 cites W2096451658 @default.
• W924562866 cites W2096549360 @default.
• W924562866 cites W2097495699 @default.
• W924562866 cites W2098737858 @default.
• W924562866 cites W2099021728 @default.

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