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- W92470166 abstract "Highly purified rat liver mitochondria catalyze oxidative dealkylation of N,N-dimethylamphetamine (I) and Methamphetamine (II). The demethylase activity is bound to the mitochondrial inner membrane or its matrix. Demethylation of N,N-dimethylaniline (1.231 nmol/mg/min) follows about two times faster than dealkylation of I (0.929 nmol/mg/min) or II (0.878 nmol/mg/min). Nitrazepam and other N-alkylamides seem to be no substrates for this mitochondrial enzyme at all. Under aerobic incubation conditions the rate of mitochondiral I-metabolism was about 1/8 of the microsomal rate, provided that both preparations have the some protein concentrations. NADPH was a much better cofactor for this reaction than NADH. The role of cytochrome P-450 as a possible essential cofactor for mitochondrial dealkylation could not be elucidated." @default.
- W92470166 created "2016-06-24" @default.
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- W92470166 date "1981-01-01" @default.
- W92470166 modified "2023-09-23" @default.
- W92470166 title "[Biotransformation of amphetamine derivatives by rat liver mitochondria / 1st communication: Oxidative dealkylation of N,N-dialkyl- and N-alkylamphetamines (author's transl)]." @default.
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