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- W92472783 abstract "Background: Despite demonstrated positive effects in a number of clinical trials, the evidence is lacking as to the impact of statins on the risk of first myocardial infarction (MI) in real life settings.Objectives: To assess the impact of real life statin utilization on the risk of first non-fatal MI.Methods: Case-control methodology using the pharmacoepidemiological information system PGRx. Data on comorbidities, risk factors and medications were obtained from medical records and patient telephone interviews. General practices (n=371) and cardiology centres (n=60) across France were employed in the study. Cases were patients with the first MI ≤ 1 month before the date of recruitment (n=2238). Controls were patients seen by a general practitioner (GP) with no restriction as to the reasons of consultation (n=2238), matched to MI cases on gender, age, frequency of visits to a doctor, date of recruitment and personal history of non-cardiovascular chronic disease. Statin exposure was defined as any utilisation in the two-year prior to date of MI in cases or recruitment date in controls. Adjusted odds ratios (OR) of the risk of first MI was estimated by multiple conditional logistic regression models. Comparative effectiveness and propensity to use of individual statin molecules were assessed.Results: The use of statins was associated with a lower MI risk (adjusted OR 0.67 [95% CI 0.56 - 0.79] for current use (within 2 months before the index date) and 0.73 [0.62 0.86] for any use within 24 months). Among individual statins, rosuvastatin was associated with the lowest MI risk (adjusted OR 0.49 [0.35 - 0.68] for any use in 24 months preceding the index date) followed by simvastatin (0.62 [0.46 - 0.84]).Conclusions: The use of statins is widespread, with related risks and costs. It is therefore essential to ensure that the benefits are also observed in actual practice. What proportion of the effect in real life is attributable to the drug’s main effect and what is attributable to the choice of indication, related health management and dosage regimen and other factors is debatable, but the overall ‘real life effect’ of statins seems to be in line with the expected magnitude." @default.
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- W92472783 date "2012-11-20" @default.
- W92472783 modified "2023-09-26" @default.
- W92472783 title "Abstract 15400: The Effect of Statins on the Risk of First Non-Fatal Myocardial Infarction: A Population-Based Observational Study Using the PGRx Information System" @default.
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