Matches in SemOpenAlex for { <https://semopenalex.org/work/W92476598> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W92476598 endingPage "107" @default.
- W92476598 startingPage "95" @default.
- W92476598 abstract "Capacitation and acrosome reaction are important prerequisites of the fertilization process. Capacitation is a highly complex phenomenon occurring in the female genital tract, rendering the spermatozoa capable of binding and fusion with the oocyte. During capacitation various biochemical and biophysical changes occur in the spermatozoa and the spermatozoal membranes. Ions and ion channels also play important roles in governing the process of capacitation by changing the fluxes of different ions which in turn controls various characteristics of capacitated spermatozoa. Along with the mobilization of ions the generation of free radicals and efflux of cholesterol also plays an important role in the capacitation state of the spermatozoa. The generation of free radical and efflux of cholesterol change the mechanodynamic properties of the membrane by oxidation of the polyunsaturated lipids and by generating the cholesterol free patches. The process of capacitation renders the spermatozoa responsive to the inducers of the acrosome reaction. The glycoprotein zona pellucida 3 (ZP3) of the egg coat zona pellucida is the potent physiological stimulator of the acrosome reaction; progesterone, a major component of the follicular fluid, is also an inducer of the acrosome reaction. The inducers of the acrosome reaction cause the activation of the various ion-channels leading to high influxes of calcium, sodium and bicarbonate. The efflux of cholesterol during the process of capacitation alters the permeability of the membrane to the ions and generate areas which are prone to fusion and vesiculation process during the acrosome reaction. This review focuses mainly on effects of the ion and ion-channels, free radicals, and membrane fluidity changes during the process of capacitation and acrosome reaction." @default.
- W92476598 created "2016-06-24" @default.
- W92476598 creator A5043626724 @default.
- W92476598 creator A5079422661 @default.
- W92476598 creator A5081821452 @default.
- W92476598 date "1999-09-01" @default.
- W92476598 modified "2023-09-27" @default.
- W92476598 title "Role of ions and ion channels in capacitation and acrosome reaction of spermatozoa." @default.
- W92476598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11250775" @default.
- W92476598 hasPublicationYear "1999" @default.
- W92476598 type Work @default.
- W92476598 sameAs 92476598 @default.
- W92476598 citedByCount "6" @default.
- W92476598 countsByYear W924765982012 @default.
- W92476598 countsByYear W924765982016 @default.
- W92476598 crossrefType "journal-article" @default.
- W92476598 hasAuthorship W92476598A5043626724 @default.
- W92476598 hasAuthorship W92476598A5079422661 @default.
- W92476598 hasAuthorship W92476598A5081821452 @default.
- W92476598 hasConcept C105702510 @default.
- W92476598 hasConcept C12554922 @default.
- W92476598 hasConcept C185592680 @default.
- W92476598 hasConcept C196843134 @default.
- W92476598 hasConcept C2776010925 @default.
- W92476598 hasConcept C2776690073 @default.
- W92476598 hasConcept C2779995066 @default.
- W92476598 hasConcept C2780301668 @default.
- W92476598 hasConcept C55493867 @default.
- W92476598 hasConcept C86803240 @default.
- W92476598 hasConcept C88972607 @default.
- W92476598 hasConcept C95444343 @default.
- W92476598 hasConceptScore W92476598C105702510 @default.
- W92476598 hasConceptScore W92476598C12554922 @default.
- W92476598 hasConceptScore W92476598C185592680 @default.
- W92476598 hasConceptScore W92476598C196843134 @default.
- W92476598 hasConceptScore W92476598C2776010925 @default.
- W92476598 hasConceptScore W92476598C2776690073 @default.
- W92476598 hasConceptScore W92476598C2779995066 @default.
- W92476598 hasConceptScore W92476598C2780301668 @default.
- W92476598 hasConceptScore W92476598C55493867 @default.
- W92476598 hasConceptScore W92476598C86803240 @default.
- W92476598 hasConceptScore W92476598C88972607 @default.
- W92476598 hasConceptScore W92476598C95444343 @default.
- W92476598 hasIssue "3" @default.
- W92476598 hasLocation W924765981 @default.
- W92476598 hasOpenAccess W92476598 @default.
- W92476598 hasPrimaryLocation W924765981 @default.
- W92476598 hasRelatedWork W1884574774 @default.
- W92476598 hasRelatedWork W1992308074 @default.
- W92476598 hasRelatedWork W1996634581 @default.
- W92476598 hasRelatedWork W2026938951 @default.
- W92476598 hasRelatedWork W2078163628 @default.
- W92476598 hasRelatedWork W2080321640 @default.
- W92476598 hasRelatedWork W2109553623 @default.
- W92476598 hasRelatedWork W2162841221 @default.
- W92476598 hasRelatedWork W2921222244 @default.
- W92476598 hasRelatedWork W3029389115 @default.
- W92476598 hasVolume "1" @default.
- W92476598 isParatext "false" @default.
- W92476598 isRetracted "false" @default.
- W92476598 magId "92476598" @default.
- W92476598 workType "article" @default.