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- W92487956 abstract "Herpes stromal keratitis (HSK) is an immunoinflammatory disease that is triggered by herpes simplex virus (HSV) infection of the cornea. Most herpetic eye disease is caused by HSV type 1 (HSV-1). Primary HSV-1 infection often occurs early in life and with minimal or no symptoms. However, during primary infections that typically occur on mucosal surfaces, the virus invades sensory neurons and is transported by a retrograde axonal transport mechanism to the neuronal cell bodies in sensory ganglia, and there establishes a life-long latent infection. During HSV-1 latency, complete viral genomes are retained in neurons, but no virions are produced. Periodic exposure to inductive signals such as stress and ultraviolet irradiation leads to HSV-1 reactivation from latency, anterograde transport, and release of infectious virions. Viral shedding in the cornea can trigger recurrent HSK, a T-cell-orchestrated inflammatory response that leads to progressive scarring and visual impairment. HSK is a leading infectious cause of corneal blindness in developed countries, and an important indication for penetrating keratoplasty. Here we review the current literature regarding the immunopathogenic mechanisms that contribute to corneal damage during HSK." @default.
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- W92487956 date "2010-01-01" @default.
- W92487956 modified "2023-09-22" @default.
- W92487956 title "Immunopathogenesis of HSV Keratitis" @default.
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- W92487956 doi "https://doi.org/10.1016/b978-0-12-374203-2.00011-7" @default.
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