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- W924966199 abstract "目的探讨脑干迷走神经复合体（DVC）区微量注射ghrelin对摄食的影响及其可能机制。方法72只雄性SD大鼠随机分成给药组和正常对照组，每组36只大鼠，行DVC区埋管手术，术后恢复7d。7d后给药组大鼠DVC区微量注射20pmol的ghrelin，正常对照组大鼠DVC区微量注射等体积生理盐水。两组分别于给药后1、2、3h取大鼠下丘脑提取RNA，应用荧光定量PCR方法检测大鼠下丘脑弓状核神经肽Y（NPY）及刺鼠色蛋白相关蛋白（AgRP）mRNA的表达情况。结果给药组大鼠给药后1、2、3h下丘脑NPYmRNA和AgRPmRNA的表达水平均明显高于正常对照组，差异有显著性（t2．79～9．12，P〈0．05）。给药组大鼠给药后2h下丘脑NPYmRNA和AgRPmRNA的表达水平明显高于给药后1h及3h组（F=16．55、10．45，q=3．89～4．45，P〈0．05），但给药后1h与3h下丘脑NPY mRNA和AgRP mRNA的表达水平比较差异无显著性（P〉0．05）。结论作用于大鼠DVC区的ghrelin可能通过下丘脑弓状核NPY、AgRP神经通路促进摄食活动。" @default.
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- W924966199 date "2009-01-01" @default.
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- W924966199 title "大鼠脑干DVC区注射ghrelin对弓状核NPY mRNA及AgRP mRNA表达的影响" @default.
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